The aim of the study is to compare, assess the optimum tools as well as the techniques and advanced features focused on prediction of diabetes diagnosis based on machine learning tactics and diabetic retinopathy using Artificial Intelligence. The literature on data science, Artificial Intelligence (AI) contains important knowledge and understanding of AI entities such as Data science, machine learning, deep learning, Medical image processing, feature extraction, classification techniques, etc. Diabetes diagnosis is a phenomenon that impacts individuals around the globe. Now, with diabetes impacting people from children to the elderly, the out-dated approaches to diabetes diagnosis should be replaced with new, time-saving technologies. There's several studies carried out by researchers to recognise and predict diabetes. Here plenty of classifiers in machine learning can be used, such as KNN, Random Tree, etc.They can save time and get more precise outcome when using these techniques to predict diabetes. Diabetic retinopathy (DR) is a typical disorder of diabetic disease that induces vision-impacting lesions in the retina. It also can turn to visual impairment if it is not addressed early. DR therapy only helps vision. Deep learning has in recent times being one of the most widely used approaches that has accomplished higher outcomes in so many fields, especially in the analysing and identification of medical image classification. In medical image processing, convolutional neural networks (CNN) using transfer learning are commonly used as a deep learning approach and they are incredibly beneficial. Key words: Diab