Deep Learning Analysis of Upright-Supine High-Efficiency SPECT Myocardial Perfusion Imaging for Prediction of Obstructive Coronary Artery Disease: A Multicenter Study

Betancur, Julián; Hu, Lien-Hsin; Commandeur, Frédéric; Sharir, Tali; Einstein, Andrew J.; Fish, Mathews B.; Ruddy, Terrence D.; Kaufmann, Philipp A.; Sinusas, Albert J.; Miller, Edward J.; Bateman, Timothy M.; Dorbala, Sharmila; Carli, Marcelo Di; Germano, Guido; Otaki, Yuka; Liang, Jiaming; Tamarappoo, Balaji; Dey, Damini; Berman, Daniel S.; Slomka, Piotr J.

doi:10.2967/jnumed.118.213538

Cited by 123 publications

(79 citation statements)

References 23 publications

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“…Dennoch muss festgestellt werden, daswie bei allen neuen Technologiennoch kein finaler Konsens [18] bez. der optimalen Protokolle erreicht ist und natürlich auch neue Artefakte auftreten [19,20] . Prinzipiell existieren momentan 2 gut verbreitete Systeme: im einen werden schwenkende Detektorköpfe verwendet, die mit Parallellochkollimatoren kombiniert sind (▶ Abb.…”

Section: Digitale Kamerasystemeunclassified

“…Allerdings ist dabei zu beachten, dass die Ergebnisse nicht notwendigerweise zwischen den Auswertepaketen austauschbar sind [22,23]. Naturgemäß gilt aktuell das Interesse der Integration von Methoden der künstlichen Intelligenz und erste Ergebnisse sind vielversprechend [19,24], wenn auch der unterstützende Charakter dieser Verfahren klar sein muss und nur in der Gesamtschau aller vorliegender Informationen und Berücksichtigung von Artefakten seine Vorteile entfaltet.…”

Section: Auswertungunclassified

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Konventionelles SPECT und neue Kamerasysteme – Möglichkeiten und Grenzen

Nekolla

2020

Nuklearmediziner

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Section: Digitale Kamerasystemeunclassified

Section: Auswertungunclassified

Konventionelles SPECT und neue Kamerasysteme – Möglichkeiten und Grenzen

Nekolla

2020

Nuklearmediziner

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“…There is a growing evidence, including large multicenter studies, that these solid-state SPECT systems demonstrate excellent diagnostic and prognostic utility in cardiac imaging. [6][7][8] In the last few years, the equipment companies have also introduced general-purpose CZT-based SPECT systems to enable applications other than cardiac imaging. These cameras benefit from improved energy and image resolution due to the CZT detectors and have demonstrated improved image quality in early clinical implementation as compared to general-purpose Angerbased systems.…”

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confidence: 99%

Do we need dedicated cardiac SPECT systems?

Slomka

2021

Journal of Nuclear Cardiology

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Dedicated cardiac SPECT scanners have significantly improved in recent years, 1 reducing imaging time and radiation dose. In particular, cardiac scanners have entered clinical practice, 2,3 which use solid-state Cadmium-Zinc-Telluride (CZT) crystal detectors and feature innovative gantry designs, focusing on the heart. These new systems allow improvement in photon sensitivity (5-8 times higher) 4,5 for cardiac imaging, as well as image resolution (up to 2 times higher). 5 While solidstate CZT detectors are more expensive than traditional NaI(Tl) crystal detectors with photomultipliers, they do have important imaging advantages. The CZT detectors have improved energy response, which significantly reduces the scatter component of measured data. They also offer superior intrinsic spatial resolution compared to conventional Anger cameras. The use of less-bulky detectors (no need for photomultipliers) has resulted in more compact scanner size which has facilitated smallfootprint dedicated cardiac camera designs with custom imaging geometries and high-sensitivity collimation. There is a growing evidence, including large multicenter studies, that these solid-state SPECT systems demonstrate excellent diagnostic and prognostic utility in cardiac imaging. [6][7][8] In the last few years, the equipment companies have also introduced general-purpose CZT-based SPECT systems to enable applications other than cardiac imaging. These cameras benefit from improved energy and image resolution due to the CZT detectors and have demonstrated improved image quality in early clinical implementation as compared to general-purpose Angerbased systems. 9,10 GE has introduced general-purpose CZT-based cameras, the Discovery NM/CT 670 and 870, equipped with conventional collimators and CT attenuation correction. These cameras are not only designed for general-purpose imaging but also targeting cardiac imaging applications. The conventional collimator design of these cameras may avoid the difficulties in cardiac imaging, specific to the multipinhole collimation and small field-of-view on the dedicated cardiac cameras. 11 It is important, however, to point out that the general-purpose CZT cameras offer the same photon sensitivity as the conventional Anger systems, because the count sensitivity is related to the collimator and not the crystal. Thus, dedicated CZT cameras with specialized collimators can achieve much higher count sensitivity, consequently allowing faster acquisitions and lower injected doses. In particular, the 19-pinhole collimator, with each pinhole operating at a different focal depth, allows stationary image acquisition. Photons are acquired simultaneously through all the pinholes, allowing improved sensitivity as compared to the conventional camera with parallel collimators and rotating heads. For example, the reported measured system sensitivity of the Discovery NM/CT 670 CZT camera was 78 counts/s/MBq 12 compared to 460 counts/ s/MBq 5 for the dedicated GE 530 CZT design. Thus, in absolute terms, the sensitivity of the gen...

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“…2 At present, there is more experience with the conventional supine/prone imaging, 4,6,7 while data about upright cardiac images are limited, particularly in female patients. 8,9 Upright imaging has some benefits as compared with a prone acquisition because the former does not require the patient to raise both hands during image collection, so body posture is stable, and body movements are reduced. Also, prone imaging affects respiration: abdominal breathing prevails over chest breathing at rest, but the prone position places pressure on the abdomen and promotes chest breathing.…”

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confidence: 99%