Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C)

Redmond, Christopher; Kitakule, Moses M.; Son, Aran; Sylvester, McKella; Sacco, Keith; Delmonte, Ottavia M.; Licciardi, Francesco; Castagnoli, Riccardo; Poli, Cecilia; Espinoza, Yasmin; Astudillo, Camila; Weber, Sarah; Sanchez, Gina A. Montealegre; Barron, Karyl S.; Magliocco, Mary; Dobbs, Kerry; Matthews, Helen; Oguz, Cihan; Su, Helen C.; Notarangelo, Luigi D.; Frischmeyer‐Guerrerio, Pamela A.; Schwartz, Daniella M.

doi:10.1136/ard-2022-223269

Cited by 4 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The percentage of SARS-CoV-2-specific CD4+ T-cells were elevated mainly in patients with neurological and respiratory involvement, suggesting predilection for these functions. Interestingly, decreased concentrations with some shock-associated serum biomarkers in patients with diarrhoea suggest that this complication may have protective effects [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Programmed Cell Death Protein-1 Regulation in Response to SARS-CoV-2 in Paediatric Multisystem Inflammatory Syndrome Temporally Associated with SARS-CoV-2: A Prospective Cohort Study

Opoka-Winiarska,

Grywalska,

Morawska-Michalska

et al. 2024

IJMS

View full text Add to dashboard Cite

The role of programmed death cell protein 1 (PD-1) has already been described in a range of various diseases, including COVID-19. This study provides new, innovative data, related to the expression of PD-1 and the risk of Paediatric Inflammatory Multisystem Syndrome, temporally associated with SARS-CoV-2 infection (PIMS-TS)—a rare, but potentially life-threatening complication of COVID-19. In this study, we evaluated the expression of PD-1 protein in patients with PIMS. Blood samples were taken from patients at the time of diagnosis (n = 33), after 6 weeks (n = 33), 3 months (n = 24), 6 months (n = 24) and 12 months (n = 8). The immunophenotypes were evaluated in flow cytometry. The control group consisted of 35 healthy children with negative SARS-CoV-2 antigen/PCR test, who were asymptomatic and had no history of allergic, autoimmune or oncological diseases. The associations between immunophenotypes, biochemical findings and clinical data were analysed. Significant increases in the expression of PD-1 for CD4+ and CD8+ T cells, compared to the control group, were observed in the day of admission, with a gradual decrease during the first weeks from initiation of treatment. This study sheds new light on the pathogenesis of PIMS-TS, emphasizing the role of PD-1 protein. Future research is essential for early risk prediction in SARS-CoV-2 patients and for devising effective clinical prevention and management strategies.

show abstract

Section: Discussionmentioning

confidence: 99%