2020
DOI: 10.1017/s1047951120004606
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Deep hypothermic circulatory arrest in cyanotic piglets is associated with increased neuronal necrosis

Abstract: Background: The contribution of neonatal cyanosis, inherent to cyanotic congenital heart disease, to the magnitude of neurologic injury during deep hypothermic circulatory arrest has not been fully delineated. This study investigates the impact of cyanosis and deep hypothermic circulatory arrest on brain injury. Methods: Neonatal piglets were randomised to placement of a pulmonary artery to left atrium shunt to create cyanosis or sham thoracotomy. At day 7, animals were randomised to und… Show more

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Cited by 5 publications
(4 citation statements)
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“…However, vasoconstriction has adverse effects, such as decreasing blood flow to high-demand tissues in the neonate, and inducing cellular hypoxia (26). Moreover, in animal models at the histological level, even cerebral neuronal necrosis (histopathological hypothermia score = 2 vs. control = 0) has been reported by Petko et al (27). Hypoxia also has metabolic consequences.…”
Section: E Ect Of Hypothermia On Newborn Ruminants a Precocial Modelmentioning
confidence: 86%
“…However, vasoconstriction has adverse effects, such as decreasing blood flow to high-demand tissues in the neonate, and inducing cellular hypoxia (26). Moreover, in animal models at the histological level, even cerebral neuronal necrosis (histopathological hypothermia score = 2 vs. control = 0) has been reported by Petko et al (27). Hypoxia also has metabolic consequences.…”
Section: E Ect Of Hypothermia On Newborn Ruminants a Precocial Modelmentioning
confidence: 86%
“…The procedure itself is a highly intensive and complicated intervention that is uncomfortable and has the risk of serious side effects including extreme hy-pothermia, bradycardia, hypoglycaemia, sepsis, skin necrosis, pulmonary hypertension, hypotension, and even death [3,4]. In animal studies, cooling a "nonhypoxic" brain increases neuronal injury and functional impairment [23]. On the other hand, cooling within 6 h of birth/ injury for 48 h or more in a gerbil model attenuates neuroanatomical damage and behavioural abnormalities more completely than after worse injury, suggesting that TH after mild HIE may be more effective than after more severe HIE [24].…”
Section: Discussionmentioning
confidence: 99%
“…The study utilized a previously described neonatal swine model of CPB [4,5,14,15]. The animal care and procedures were approved by the Institutional Animal Care and Use Committee in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.…”
Section: Experimental Designmentioning
confidence: 99%
“…Ten neonatal female Yorkshire piglets underwent 3 h of CPB (flow rate > 100 mL/kg/min) at 34 • C using either standard hyperoxic oxygenation (n = 5, PaO 2 > 300 mmHg) or controlled normoxic oxygenation (n = 5, PaO 2 < 150 mmHg). The perioperative preparation, CPB circuitry, priming, and monitoring methods are described elsewhere [4,5,14,15]. Detailed descriptions of the operative technique, tissue processing, and molecular assays are provided in the Supplementary Materials.…”
Section: Experimental Designmentioning
confidence: 99%