Deep Eutectic Solvents toward the Detection and Extraction of Neurotransmitters: An Emerging Paradigm for Biomedical Applications

Kaur, Harjot; Siwal, Samarjeet Singh; Kumar, Vinod; Thakur, Vijay Kumar

doi:10.1021/acs.iecr.3c00410

Cited by 8 publications

(4 citation statements)

References 98 publications

(148 reference statements)

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“…As shown in entries 6 and 7 of Table , the catalytic activity of ZnCl 2 /Urea and ZnCl 2 /ChCl was found to be lower than ZnCl 2 . The formation of DES was a result of the interaction between the hydrogen-bonding donor and the hydrogen-bonding acceptor. , In ZnCl 2 /Urea and ZnCl 2 /ChCl, the Zn 2+ already interacted with the CO of urea and −OH of ChCl, which hinders activition of the substrate. The results further confirmed that Zn 2+ served as the primary active site in the catalyst.…”

Section: Resultsmentioning

confidence: 99%

Synergistic Catalysts of Lewis Acid and Brønsted Acid for Highly Efficient Preparation of Bisphenol Compounds

Shang,

Feng,

Jiang

et al. 2024

Ind. Eng. Chem. Res.

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Bisphenol compounds play a pivotal role as essential diol monomers in the synthesis of numerous engineering plastics. However, conventional methods for their preparation often involve the use of concentrated inorganic acids, leading to significant environmental pollution and equipment corrosion. Herein, we developed a strong inorganic acid-free synergistic catalytic system consisting of a Lewis−Brønsted acid catalyst composed of ZnCl 2 and 3mercaptopropionic acid. This system enabled the highly efficient preparation of bisphenol compounds through the Friedel−Crafts alkylation reaction of ketones with phenols or phenoxyethanol. The highest selectivity of 9,9-bis[4-(2hydroxyethoxy)phenyl]fluorene can reach 96.4% at 110 °C for 2 h, which was higher than that of the traditional sulfuric acid method with a selectivity of 85.0%. A mechanistic study revealed that the carbonyl group of the ketone was first activated by the coordination ability of Zn 2+ from the Lewis acid, which facilitated the subsequent protonation process initiated by the acidic site of Brønsted acid.

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Section: Resultsmentioning

confidence: 99%

Synergistic Catalysts of Lewis Acid and Brønsted Acid for Highly Efficient Preparation of Bisphenol Compounds

Shang,

Feng,

Jiang

et al. 2024

Ind. Eng. Chem. Res.

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“…When the synthesis is carried out in ionic liquids (ILs), the process is known as an ionothermal synthesis. ILs are molten salts with melting points less than 100 °C and have been considered environmentally friendly solvents, making them promising materials for industrial applications . Thomas and his team synthesized porous crystalline COFs via an ionothermal technique .…”

Section: Cofs Their Synthetic Methods and Propertiesmentioning

confidence: 99%

Covalent–Organic Framework-Based Materials in Theranostic Applications: Insights into Their Advantages and Challenges

Kaur,

Siwal,

Saini

et al. 2024

ACS Omega

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Nanomedicine has been essential in bioimaging and cancer therapy in recent years. Nanoscale covalent−organic frameworks (COFs) have been growing as an adequate classification of biomedical nanomaterials with practical application prospects because of their increased porosity, functionality, and biocompatibility. The high sponginess of COFs enables the incorporation of distinct imaging and therapeutic mechanisms with a better loading efficiency. Nevertheless, preliminary biocompatibility limits their possibility for clinical translation. Thus, cutting-edge nanomaterials with high biocompatibility and improved therapeutic efficiency are highly expected to fast-track the clinical translation of nanomedicines. The inherent effects of nanoscale COFs, such as proper size, modular pore geometry and porosity, and specific postsynthetic transformation through simple organic changes, make them particularly appealing for prospective nanomedicines. The organic building blocks of COFs may also be postmodified for particular binding to biomarkers. The exceptional features of COFs cause them to be an encouraging nanocarrier for bioimaging and therapeutic applications. In this review, we have systematically discussed the advances of COFs in the field of theranostics by providing essential features of COFs along with their synthetic methods. Further, the applications of COFs in the field of theranostics (such as drug delivery systems, photothermal, and photodynamic therapy) are discussed in detail with the help of available literature to date. Furthermore, the advantages of COFs over other materials for therapeutics and drug delivery are discussed. Finally, the review concludes with potential future COF applications in the theranostic field.

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“…The application of DESs as green solvents in detecting and extracting NTs is described in detail for the first time [77]. Various methods, such as electrochemical [78], positron-emission tomography [79], optical [80], and microdialysis [81], are available for sensing NTs.…”

Section: Des As Catalystmentioning

confidence: 99%

Green Solvents in Organic Synthesis

Verma

2024

Solvents - Dilute, Dissolve, and Disperse - Insights on Green Solvents and Distillation

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Solvents are substances that are liquid during application and will dissolve other substances, which can be recovered unchanged on the removal of the solvent. The concept of green solvents indicates the target to decrease the environmental impact resulting from the use of solvents in chemical production. Green solvents are solvents of low toxicity, environment-friendly bio solvents, and less hazardous than traditional organic solvents. The solvents which are not harmful to the environment and human beings are called green solvents. Traditional solvents can be replaced with green solvents as a long-term way to reduce and minimize environmental deterioration. Solvents like ionic liquids and deep eutectic mixtures can be used as green solvents and are used as part of the class of green solvents in organic synthesis. The review focuses on the properties, applications, and limitations of these solvents.

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Deep Eutectic Solvents toward the Detection and Extraction of Neurotransmitters: An Emerging Paradigm for Biomedical Applications

Cited by 8 publications

References 98 publications

Synergistic Catalysts of Lewis Acid and Brønsted Acid for Highly Efficient Preparation of Bisphenol Compounds

Synergistic Catalysts of Lewis Acid and Brønsted Acid for Highly Efficient Preparation of Bisphenol Compounds

Covalent–Organic Framework-Based Materials in Theranostic Applications: Insights into Their Advantages and Challenges

Green Solvents in Organic Synthesis

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