Deep Eutectic Solvent: An Efficient and Recyclable Catalyst for Synthesis of Thioethers.

Abstract

An efficient nucleophilic aromatic substitution (SNAr) reaction for C−S bond formation using greener and reusable deep eutectic solvent (DES) has been described. A variety of thioethers are synthesized in impressive yields (88‐98 %) by reacting various electron‐deficient aryl/alkyl halides and thiols. This protocol is valid to aryl halides with diverse functional groups such as aldehydes, carboxylic acids, nitro and nitrile groups. The attractive features of this approach includes metal/ligand free conditions, absence of organic solvents, short reaction time, easy isolation of products and simple work up procedure. This effective catalytic system is economically viable, environmentally benign and recyclable up to four cycles without significant loss in activity.

Choline Hydroxide Promoted Synthesis of N‐Aryl Anthraquinone Derivatives: Metal Free Approach to Ullmann Coupling Reactions

“…Based on the experimental observations and literature reports the reaction mechanism for formation of N ‐aryl AQ in the presence of ChOH is depicted in Figure . The enhanced reactivity of 1‐bromo‐AQ towards N ‐arylation reaction is due to electron‐withdrawing carbonyl group suggesting S N Ar mechanistic pathway.…”

“…Choline hydroxide (ChOH) is an environmentally benign, water soluble and biodegradable task‐specific ionic liquid which displays strong basicity . In our prior work we have reported C−N, C−O and C−S coupling reactions catalysed by deep eutectic solvents (DES) . In continuation of our endeavours in developing environmentally benign catalysts and overcoming the afore mentioned limitations, we wish to report choline hydroxide catalysed metal free protocol for synthesis of N ‐aryl anthraquinone derivatives.…”

“…[35][36][37] In our prior work we have reported CÀN, CÀO and CÀS coupling reactions catalysed by deep eutectic solvents (DES). [38][39][40] In continuation of our endeavours in developing environmentally benign catalysts and overcoming the afore mentioned limitations, we wish to report choline hydroxide catalysed metal free protocol for synthesis of N-aryl anthraquinone derivatives. To the best of our knowledge this is a conceptually new metal free methodology applied first time for the synthesis of N-aryl anthraquinone derivatives.…”

A Triple-Emission Fluorescent Probe for Discriminatory Detection of Cysteine/Homocysteine, Glutathione/Hydrogen Sulfide, and Thiophenol in Living Cells

“…TQC , NBD-SPh, NBD-SH , and DNB-SPh were synthesized according to the literature methods. − The solutions of NBD-N-Cys/Hcy and NBD-S-GSH in this work were prepared from NBD-Cl with Cys, Hcy, and GSH in aqueous solution (containing 30% acetonitrile) …”

Bismuth Oxychloride Nanoparticles: Deep Eutectic Solvent Assisted Synthesis and Application in an Electrochemical Nickel Sensor

“…Additionally, the cost of synthesis and raw materials for DESs is very cheap [5] . Therefore, DESs are also attractive alternatives for the synthesis of various materials such as thioethers, [6] monodispersed silver nanocrystals, [7] gold nano‐sheets, [8] carbon dots, [9] bismuth vanadate microtubes, [10] and bismuth oxychloride (BiOCls), [11] and so forth.…”