“…To determine the RBC morphology quickly and unbiasedly, machine learning approaches are used nowadays, similar to other aspects in hematology and transfusion medicine [24,84,85]. In the context of RBCs, artificial neural networks and deep learning-based techniques have been used to assess cell phenotypes both in stasis [57,82,[86][87][88] and during deformation [71,83,[89][90][91]. Kim et al [82] employed a generative adversarial network to evaluate RBC phenotypes based on phase images obtained by digital holographic microscopy at rest.…”