Deep cerebral vein thrombosis associated with iron deficiency anaemia in adults

Cerebral Venous Thrombosis Secondary to Severe Iron Deficiency Anemia: A Case Study

“…As a result, anemic hypoxia consequent to IDA could precipitate situations of increased metabolic stress predominantly in susceptible areas of the brain like basal ganglia and thalamus, due to end arterial blood supply (Balci et al, 2007). This fact could elucidate association of reversible focal deficits and stroke with IDA noticed by some authors (Hartfield et al, 1997;Young et al, 1983;Hart & Kanter, 1990).…”

“…However, only a few cases of adults with IDA have been reported (Balci et al, 2007;Ho et al, 2008;Ogata et al, 2008;Kinoshita et al, 2006;Aoki & Sakai, 1989). However, some of these cases were accompanied by other recognized risk factors of CVT, such as dehydration (Kinoshita et al, 2006), a hypercoagulable state (acquired protein C and protein S deficiency) (Ho et al, 2008), and cryoglobulinemia (Ho et al, 2008).…”

Uterine myomatosis and portal vein thrombosis: a rare association

“…13 Further poor oxygenation due to reduced hemoglobin levels lead to metabolic stress and endothelial damage. 14 The portal vein forms at the junction of the splenic vein and the superior mesenteric vein behind the pancreatic head. Thrombosis of the portal vein can occur due to hepatic causes like cirrhosis or malignancies or extra hepatic causes.…”

Iron deficiency decreases hemolysis in sickle cell anemia

“…13,14 On the other hand, iron deficiency may have a direct, vaso-protective effect in sickle cell patients, apart from its inhibitory effect on hemolysis: iron deficiency anemia up-regulates vascular nitric oxide synthase in animals, 15 and in humans it increases NO production even in the absence of anemia. 16 …”