Deep Capillary Macular Perfusion Indices Obtained with OCT Angiography Correlate with Degree of Nonproliferative Diabetic Retinopathy

Saurabh, Kumar; Abu-Amero, Khaled K.; Chalam, Kakarla V

doi:10.5301/ejo.5000948

Cited by 65 publications

(52 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies also suggest that OCTA parameter alterations in the deep vascular layer are affected more severely than in the superficial vascular layer in NPDR [10, 11, 14-16, 17, 21, 23, 26]. OCTA parameters at the deep vascular layer were most significantly affected in patients with DME [4, 29-32].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Fractal dimension in patients with NPDR was decreased in both retinal vascular layers compared to control subjects [13, 25, 27]. In contrast, another group reported increased fractal dimension in both vascular layers of patients with NPDR compared to control subjects [23]. In patients with PDR, significant FAZ area enlargement and a decrease of FAZ circularity and vessel density was detected in both superficial and deep vascular layers [28].…”

Section: Octa Parameters In the Superficial Deep And/or Intermediatmentioning

confidence: 99%

“…Vessel density in both superficial and deep vascular layers was significantly decreased in patients with established NPDR [17, 20, 21-25]. A progressive reduction of the deep-vascular-layer vessel density was noted from 25.23% in mild NPDR, 20.16% in moderate NPDR, to 11.16% in severe NPDR [23]. In patients with NPDR without DME, visual acuity was correlated with capillary loss in the deep vascular layer [26].…”

Section: Octa Parameters In the Superficial Deep And/or Intermediatmentioning

confidence: 99%

See 2 more Smart Citations

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Dimitrova¹,

Chihara²

2019

Ophthalmologica

View full text Add to dashboard Cite

The aim of this narrative mini review is to analyze optical coherence tomography angiography (OCTA) parameters from reports that involved both superficial and deep vascular layers in patients with diabetes and to assess their relevance for the pathogenesis of diabetic retinopathy (DR). Papers published from January 2015 to August 2018 describing the use of OCTA in diabetes were identified and reviewed through a Medline/PubMed search. OCTA studies suggest that parameters are altered in patients with diabetes in all retinal vascular layers. From all included studies that evaluated both the superficial and the deep vascular layer, a number of studies suggested that the deep vascular layer was affected at an earlier stage of DR. OCTA parameter alterations were more prominent in the deep vascular layer than in the superficial vascular layer in patients with DR, and deep-vascular-layer alterations were most evident in patients with diabetic macular edema. Regarding that retinal venules originate from the deep vascular layer of the retina, alteration of OCTA parameters at the deep vascular layer in diabetic patients may imply a predominant affection of the venous side of the retinal vascular system in the pathogenesis of DR.

show abstract

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Octa Parameters In the Superficial Deep And/or Intermediatmentioning

confidence: 99%

Section: Octa Parameters In the Superficial Deep And/or Intermediatmentioning

confidence: 99%

See 1 more Smart Citation

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Dimitrova¹,

Chihara²

2019

Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…On the other hand, vascular disruption in eyes suffering from DR can be so pronounced that in two eyes deep FAZ was not completely contained in the 3 3 3-mm scan. This could be explained considering that FAZ is usually larger at deep capillary plexus, and, as already mentioned, deep vascular layer disruption is more pronounced in DR. 17,28 With regard to vessel density, our study showed a poor interchangeability across different angiocubes for every plexus and every subgroup. Several aspects should be considered to interpret this finding.…”

Section: Discussionmentioning

confidence: 99%

“…The deep plexus is considerably disrupted in DR patients, especially in cases of severe retinopathy. 28 In addition, diabetic macular edema is associated with the involvement of the deeper retinal layers and, thus, it can also affect FAZ measure. 29,30 Because the 12 3 12-mm angiocube has a poor resolution, it can be more difficult to unequivocally outline FAZ area compared with smaller scans.…”

Section: Discussionmentioning

confidence: 99%

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Rabiolo

Gelormini

Marchese

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To investigate the macular quantitative parameters interchangeability of three different optical coherence tomography angiography (OCT-A) angiocubes (i.e., 3 3 3, 6 3 6, and 12 3 12 mm) on healthy subjects and patients affected by diabetic retinopathy (DR) and to assess the interrater reliability of such indices across the different scan protocols. METHODS.Retrospective study involving 20 eyes of healthy subjects and 20 eyes with DR. All eyes underwent swept-source OCT-A with 3 3 3-, 6 3 6-, and 12 3 12-mm angiocubes centered on the fovea. Foveal avascular zone (FAZ) area and vessel density on 3 3 3-, 6 3 6-, and 12 3 12-mm macular scans were calculated by three independent operators at all retina, superficial, deep, and choriocapillary vascular layers. Interchangeability and interrater reliabilities were estimated using intraclass correlation coefficient (ICC).RESULTS. Interscan reproducibility of FAZ area was very strong (ICC > 0.85) at every plexus. On the contrary, vessel density values significantly varied across different scan sizes (ICC < 0.51). Intrascan interrater reliability was high for all retina and superficial FAZ areas, while it was satisfactory at deep capillary plexus only for 3 3 3-mm scan.CONCLUSIONS. FAZ area at all plexuses is a robust parameter even if calculated on angiocubes with different size. However, interrater reliability is higher when measured in smaller scans. Conversely, vessel density results depend on the size of angiocube, although their interrater reliability is extremely high. Studies involving OCT-A should take into consideration that scan size may influence macular perfusion parameters and interrater reliability.

show abstract

Enlargement of the foveal avascular zone detected by optical coherence tomography angiography in diabetic children without diabetic retinopathy

Niestrata-Ortiz

Fichna

Stankiewicz

et al. 2019

Graefes Arch Clin Exp Ophthalmol

View full text Add to dashboard Cite

Deep Capillary Macular Perfusion Indices Obtained with OCT Angiography Correlate with Degree of Nonproliferative Diabetic Retinopathy

Cited by 65 publications

References 31 publications

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Implication of Deep-Vascular-Layer Alteration Detected by Optical Coherence Tomography Angiography for the Pathogenesis of Diabetic Retinopathy

Macular Perfusion Parameters in Different Angiocube Sizes: Does The Size Matter in Quantitative Optical Coherence Tomography Angiography?

Enlargement of the foveal avascular zone detected by optical coherence tomography angiography in diabetic children without diabetic retinopathy

Contact Info

Product

Resources

About