Deep Cancers in Uncontrolled Diabetes and Weight Loss

Abstract

An unexpected weight loss can be the first manifestation of deep cancers, more frequent in diabetes. How many are detected by a Thoraco-Abdominal-Pelvic Scanner (TAP)? From the register of TAP-scanners performed in our diabetology department from 2010 to 2019, we selected those indicated for unexplained weight loss. Binary logistic regression analysis was performed to identify clinical and biological characteristics related to cancer. Highlights• Weight loss and deep cancers are more frequent in subjects with diabetes.• In 359 subjects admitted for uncontrolled diabetes and weight loss, we performed a CT-scanner and found 22 deep cancers (6.2%): pancreas, lungs, liver and kidneys.• The cancers were more frequent for important weight loss when Gamma-Glutaryl-Transferases were increased.