Deep Brain Stimulation Surgery for Essential Tremor in a Patient with Type A Hemophilia

Palsma, Ryan; Gravbrot, Nicholas; Bina, Robert; Agastya, Manas; Kasoff, Willard S.

doi:10.1016/j.wneu.2020.03.174

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Up to now, literature regarding such constellations is scarce, and only a few case reports are available dealing with hemostaseological concepts going alongside intracranial procedures. 5,6 As a consequence, surgeons and anaesthesiologist are often reserved when indicating surgical interventions in HA patients. As an example, the standard procedure of resecting the astrocytoma upon diagnosis was not performed in the second patient due to known bleeding disorder.…”

Section: Discussionmentioning

confidence: 99%

Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures

Kocher

Seeber

Kerschbaumer

et al. 2021

Therapeutic Advances in Hematology

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Patients with haemophilia A (HA) undergoing neurosurgical procedures have a high risk of haemorrhage with potential fatal outcome. Here, we present a successful perioperative haemostatic concept applying an extended half-life factor VIII (EHL FVIII), Efmoroctocog alfa, in two patients with HA undergoing neurosurgery for paramedian right-sided disc herniation (case 1) and astrocytoma (case 2). After adequate EHL FVIII treatment the surgical procedures were performed without any bleeding complications despite the high-risk interventions. Laboratory measurements confirmed stable FVIII levels throughout the hospital stay. We suggest close interdisciplinary collaboration between involved clinicians as mandatory prerequisite for an optimized perioperative management in patients with HA. The presented cases indicate, that the increased stability, safety and fewer injections provide a rationale to use EHL FVIII products in HA patients undergoing surgical interventions with a very high bleeding risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures

Kocher

Seeber

Kerschbaumer

et al. 2021

Therapeutic Advances in Hematology

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show abstract

“…There is a limited number of reports on anesthetic management of patients with hemophilia undergoing neurosurgical procedures [3][4][5]. Aouba A et al (2010) described a patient with hemophilia, who underwent successful removal of a temporo-parietal glioblastoma [3].…”

Section: Discussionmentioning

confidence: 99%

Cervical Spinal Surgery of a Patient with Hemophilia and Ehlers-Danlos Syndrome: Anesthetic Considerations

Soghomonyan¹,

Khan²,

L³

et al. 2021

austinjanesthesiaandanalgesia

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Spinal surgery carries the risk of significant intraoperative blood loss requiring blood transfusions. In patients with coexisting coagulopathy the risk is substantially higher, and proper correction of coagulation deficiency is mandatory to avoid major and uncontrolled blood loss and hematoma formation with spinal cord compression. We present a clinical case of successful cervical tumor removal in a patient with coexisting hemophilia A and Ehlers-Danlos syndrome. Coordination of the treatment plan between anesthesia providers, surgeons, and the hematological service helped to uneventfully remove the tumor and avoid perioperative complications.

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Drug-resistant epilepsy in children with hemophilia: how can we do it surgically?

Mingkun

Chen

et al. 2022

British Journal of Neurosurgery

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Deep Brain Stimulation Surgery for Essential Tremor in a Patient with Type A Hemophilia

Cited by 4 publications

References 15 publications

Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures

Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures

Cervical Spinal Surgery of a Patient with Hemophilia and Ehlers-Danlos Syndrome: Anesthetic Considerations

Drug-resistant epilepsy in children with hemophilia: how can we do it surgically?

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