Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor

Hamani, Clement; Machado, Danilo C.; Hipólide, Débora Cristina; Dubiela, Francisco Paulino; Suchecki, Deborah; Macedo, Carlos Eduardo; Tescarollo, Fabio; Martins, Uilton; Covolan, Luciene; Nóbrega, José N.

doi:10.1016/j.biopsych.2011.08.025

Cited by 148 publications

(122 citation statements)

References 43 publications

(66 reference statements)

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“…Animals were stimulated at 50 mA, 90 ms of pulse width, and 130 Hz. These settings are similar to previous publications both from our laboratory (Hamani et al, 2010a(Hamani et al, , 2012a and others (see Introduction). The sham condition consisted of the animals being connected to the stimulation equipment but not receiving any stimulation.…”

Section: Electrical Stimulationsupporting

confidence: 75%

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Pushparaj

Hamani

et al. 2012

Neuropsychopharmacol

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Pharmacological inactivation of the granular insular cortex is able to block nicotine-taking and -seeking behaviors in rats. In this study, we explored the potential of modulating activity in the insular region using electrical stimulation. Animals were trained to self-administer nicotine (0.03 mg/kg per infusion) under a fixed ratio-5 (FR-5) schedule of reinforcement followed by a progressive ratio (PR) schedule. Evaluation of the effect of stimulation in the insular region was performed on nicotine self-administration under FR-5 and PR schedules, as well on reinstatement of nicotine-seeking behavior induced by nicotine-associated cues or nicotine-priming injections. The effect of stimulation was also examined in brain slices containing insular neurons. Stimulation significantly attenuated nicotine-taking, under both schedules of reinforcement, as well as nicotine-seeking behavior induced by cues and priming. These effects appear to be specific to nicotine-associated behaviors, as stimulation did not have any effect on food-taking behavior. They appear to be anatomically specific, as stimulation surrounding the insular region had no effect on behavior. Stimulation of brain slices containing the insular region was found to inactivate insular neurons. Our results suggest that deep brain stimulation to modulate insular activity should be further explored.

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Section: Electrical Stimulationsupporting

confidence: 75%

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Pushparaj

Hamani

et al. 2012

Neuropsychopharmacol

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“…The dystrophic action of stress was reported in animal models of depression (Table 1). Animals exposed to chronic stress such as chronic mild stress or social deprivation displayed a decrease in the protein levels of BDNF and an increase of its receptor tyrosine-kinase TrkB in several brain regions including hippocampus (DG, CA1 and CA3), frontal cortex and midbrain [163][164][165][166][167][168]. BDNF-deficient mice or with specific knockdown of BDNF in the DG also displayed depressive-like behaviors [169,170].…”

Section: Neurotrophins Modulation By 5-ht Antidepressantsmentioning

confidence: 99%

Long-Term Adaptive Changes Induced by Antidepressants: From Conventional to Novel Therapies

Mnie-Filali¹,

Abrial²,

Lambás‐Señas³

et al. 2013

Mood Disorders

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“…In these cases the normally observed connectivity between the PFC and amygdala via the VMPFC appears to be disrupted, suggesting However, the electrical disruption of VMPFC activity, particularly in the subgenual cingulate is a promising treatment of seeminglyintractable depression [86,87]. Whether psychosocial interventions can also act upon this deregulated VMPFC-subcortical network is a question for future research.…”

Section: The Vmpfc and Subgenual Cingulate As A Subcortial-pfc Bridgementioning

confidence: 99%

Towards a neuroimaging biomarker of depression vulnerability

Farb

Segal

Anderson

2011

Translational Neuroscience

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Major depressive disorder (MDD) is a pervasive and debilitating illness, with a recurrent course and chronic prognosis. Although effective treatments for MDD exist, there is a pressing need to characterize relapse vulnerability in order to design effective prophylactic care. To date, heterogeneity within depression neuroimaging research has made it difficult to establish a reliable biomarker of disorder susceptibility. In this paper, we review neuroimaging evidence for the assessment of MDD vulnerability, theorizing that current findings can be broadly distinguished between those indicating the presence of depressive episodes and those indicating MDD vulnerability during symptom remission. We argue that unlike the amygdala hyperactivity and prefrontal hypoactivity observed during MDD episodes, prefrontal hyperactivity may be a characteristic of dysphoric cognition during symptom remission that indicates MDD vulnerability and relapse risk. Drawing on current research of normative emotion regulation, we describe a potential test of MDD vulnerability, employing emotional challenge paradigms that induce cognitive reactivity -the increased endorsement of negative self-descriptions during a transient dysphoric mood. Relative to a normative model of prefrontal function, the neuroimaging assessment of cognitive reactivity may provide a reliable indicator of MDD vulnerability, advancing the field of biomarker research as well as the delivery of preventative treatment on an individual basis.

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Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor

Abstract: vmPFC stimulation was effective in a chronic model of depression. Our results suggest that the integrity of the serotonergic system is important for the anti-anhedonic-like effects of DBS but question a direct role of hippocampal BDNF.

Cited by 148 publications

References 43 publications

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Electrical Stimulation of the Insular Region Attenuates Nicotine-Taking and Nicotine-Seeking Behaviors

Long-Term Adaptive Changes Induced by Antidepressants: From Conventional to Novel Therapies

Towards a neuroimaging biomarker of depression vulnerability

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