Deep brain stimulation of the entorhinal cortex modulates CA1 theta-gamma oscillations in mouse models of preclinical Alzheimer's disease

Luo, Yinpei; Sun, Yuwei; Han, Wen; Wang, Xing; Zheng, Xiaolin; Ge, Hongfei; Yin, Yilong; Wu, Xiaoying; Li, Weina; Hou, Wensheng

doi:10.1016/j.bbe.2022.12.010

Cited by 3 publications

(5 citation statements)

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“…The MWM test is a widely employed behavioral paradigm for assessing spatial learning and memory abilities in rodents, demonstrating heightened sensitivity to hippocampal memory impairments (Possin et al, 2016 ). In our MWM task, the performance of AD group exhibited a pronounced deficit relative to WT group, aligning consistently with prior research outcomes (Luo et al, 2023 ). During the hidden platform training, AD mice exhibited prolonged latency in locating the platform, indicative of compromised spatial learning abilities in this cohort.…”

Section: Discussionsupporting

confidence: 90%

“…The deposition of amyloid beta and the formation of neurofibrillary tangles are the pathological processes associated with AD (Yokoyama et al, 2022 ). These pathological features have the potential to disrupt synaptic and neuronal activity, causing network abnormalities in various brain regions (Casula et al, 2022 ; Luo et al, 2023 ; Pless et al, 2023 ). In the brains of AD patients, various neurophysiological features have been detected, including hyperexcitability in the precuneus cortex (Casula et al, 2023 ) and impairment of cerebellar-cortical plasticity mechanisms (Di Lorenzo et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Zhang,

Guo,

et al. 2024

Front. Neurosci.

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IntroductionIn our study, we applied transcranial magneto-acoustic stimulation (TMAS), a technique based on focused ultrasound stimulation within a static magnetic field, in the APP/PS1 mouse model of Alzheimer's disease (AD) to explore the feasibility of TMAS on improving AD related spatial memory deficits and abnormal neural oscillations.MethodsThe mice treated with TMAS once daily for 21 days. We recorded local field potential signals in the hippocampal CA1 region of the mice after TMAS treatment with in-vivo electrophysiology and evaluated the neural rehabilitative effect of TMAS with sharp-wave ripple (SWR), gamma oscillations during SWRs, and phase-amplitude coupling (PAC). The spatial memory function of the mice was examined by the Morris water maze (MWM) task.ResultsWe found that TMAS improved the performance of MWM related spatial cognitive functions compared with AD group. Furthermore, our results implied that TMAS alleviated abnormalities in hippocampal SWRs, increased slow gamma power during SWRs, and promoted theta-slow gamma phase-amplitude coupling. These findings suggest that TMAS could have a positive influence on spatial memory through the modulation of neural oscillations.DiscussionThis work emphasizes the potential of TMAS to serve as a non-invasive method for Alzheimer's disease rehabilitation and promote the application of TMAS for the treatment of more neurological and brain aging diseases in the future.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Zhang,

Guo,

et al. 2024

Front. Neurosci.

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“…Additionally, 130 Hz DBS in the EC for 6 weeks was found to be effective in treating memory disorders and Aβ pathology in aged and young TgCRND8 mice (Xia et al, 2017). According to a recent study, 21 days of 10 Hz DBS not only improved pathological hallmarks of AD but also could restore impaired hippocampal theta and gamma power and theta-high gamma coupling, suggesting the crucial role of the EC neuronal activity in regulating hippocampal neural networks (Luo et al, 2023). These results suggest that modulating EC neuronal activity may be a promising therapeutic target for AD.…”

Section: Alteration Of Ec Oscillatory Activity In Admentioning

confidence: 93%

Impairment of entorhinal cortex network activity in Alzheimer’s disease

Karimani,

Asgari Taei,

Abolghasemi-Dehaghani

et al. 2024

Front. Aging Neurosci.

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The entorhinal cortex (EC) stands out as a critical brain region affected in the early phases of Alzheimer’s disease (AD), with some of the disease’s pathological processes originating from this area, making it one of the most crucial brain regions in AD. Recent research highlights disruptions in the brain’s network activity, characterized by heightened excitability and irregular oscillations, may contribute to cognitive impairment. These disruptions are proposed not only as potential therapeutic targets but also as early biomarkers for AD. In this paper, we will begin with a review of the anatomy and function of EC, highlighting its selective vulnerability in AD. Subsequently, we will discuss the disruption of EC network activity, exploring changes in excitability and neuronal oscillations in this region during AD and hypothesize that, considering the advancements in neuromodulation techniques, addressing the disturbances in the network activity of the EC could offer fresh insights for both the diagnosis and treatment of AD.

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“…In one study, researchers implanted stimulating electrodes in 4-month-old APP/PS1 mice, a model of preclinical AD [24]. DBS at 100 μA, 10Hz and 90μs was delivered for 1h per day in 21 days which increased the power of theta and gamma oscillations.…”

Section: Modulation Of Neural Oscillations Can Improve Memory Perform...mentioning

confidence: 99%

“…There are two major frameworks in the neuroscience field-the single neuron representation, which focuses primarily on the intrinsic properties of individual neurons and the neural network representation, which entails a group of neurons creating a common electric field and potential [1]. Neural oscillations consist of rhythmic neuronal activities of varying frequency bands: delta (2-4 Hz), theta (4-8 Hz), alpha (8)(9)(10)(11)(12), beta (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), and gamma (30-100 Hz). Oscillations can be explained by both of these representations.…”

Section: Introductionmentioning

confidence: 99%

Role of neural oscillations modulating long term potentiation to Alzheimer's Disease

Liu

2023

TNS

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Neural oscillations are key in forming long-term memory. Theta and gamma oscillations have particularly gained substantial interest over the year for their involvement in memory formation. Theta-Gamma Coupling (TGC) has proven to be critical in memory formation processes. However, the relationship between neural oscillations and molecular synaptic mechanisms, including Long Term Potentiation (LTP) and Long-Term Depression (LTD) has yet to be fully understood. Furthermore, the modulation of neural oscillations has emerged as a novel way of treating Alzheimers Disease (AD) and Mild Cognitive Impairments (MCI). Various methods have been exploited, including optogenetics and Deep Brain Stimulation (DBS). While offering promising results including enhanced memory performance and restored brain oscillations, such modulations applicability to clinical trials in human and potential side effects are still in doubt. In this review, we elucidated on the link between LTP and oscillations, assessed the various neuromodulation techniques introduced by recent studies and also provided insights into future research directions to optimize these present methods of neural modulation.

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Deep brain stimulation of the entorhinal cortex modulates CA1 theta-gamma oscillations in mouse models of preclinical Alzheimer's disease

Cited by 3 publications

References 61 publications

Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Transcranial magneto-acoustic stimulation improves spatial memory and modulates hippocampal neural oscillations in a mouse model of Alzheimer's disease

Impairment of entorhinal cortex network activity in Alzheimer’s disease

Role of neural oscillations modulating long term potentiation to Alzheimer's Disease

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