Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

Wireless-Powering Deep Brain Stimulation Platform Based on 1D-Structured Magnetoelectric Nanochains Applied in Antiepilepsy Treatment

“…Since the ANT is involved in seizure propagation and spreading via corticothalamic connections, mammillary bodies, and the Papez circuit, stimulation of the ANT is considered an effective approach to suppress abnormal neural activity originating from epilepsy, as shown in Figure E on the left. Numerous studies have shown that chronic ANT stimulation exerts a protective effect on hippocampal neurons by desynchronizing neural networks and inhibiting neuronal apoptosis. , Thus, open field tests were performed to determine the influence of magnetoelectric therapy mediated by ANT on the behavioral effects of epileptic rats. As shown in Figure A,B, rats in the FBC+MS group traveled longer distances than those in the other two groups on day 10, and the total distance was comparable to that in the sham group, indicating reduced anxiety-like behavior caused by epilepsy.…”

“…Numerous studies have shown that chronic ANT stimulation exerts a protective effect on hippocampal neurons by desynchronizing neural networks and inhibiting neuronal apoptosis. 35,36 Thus, open field tests were performed to determine the influence of magnetoelectric therapy mediated by ANT on the behavioral effects of epileptic rats. As shown in Figure 7A,B, rats in the FBC+MS group traveled longer distances than those in the other two groups on day 10, and the total distance was comparable to that in the sham group, indicating reduced anxiety-like behavior caused by epilepsy.…”