Deep brain stimulation in the globus pallidus to treat dystonia: Electrophysiological characteristics and 2 years’ follow-up in 10 patients

Magariños-Ascone, C; Regidor, Ignacio; Gómez-Galán, Marta; Cabañés-Martínez, Lidia; Figueiras-Méndez, R

doi:10.1016/j.neuroscience.2008.01.001

Cited by 50 publications

(38 citation statements)

References 73 publications

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“…Importantly, targets for adult and pediatric patients with dystonia remain the same, as most centers have used the GPi as the target. A further study 34 involving GPi DBS that examined 10 patients, of which 3 were children, also found significant improvements in both dystonic movements and functional disability after 2 years. One of the largest case series to date 54 that specifically included pediatric patients involved 12 patients with childhood onset dystonia, of which 8 had primary and 4 secondary dystonia.…”

Section: Current Indications For Pediatric Dbsmentioning

confidence: 89%

Current and future indications for deep brain stimulation in pediatric populations

Lipsman¹,

Ellis²,

Lozano³

2010

FOC

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Deep brain stimulation (DBS) has proven to be an effective and safe treatment option in patients with various advanced and treatment-refractory conditions. Thus far, most of the experience with DBS has been in the movement disorder literature, and more specifically in the adult population, where its use in conditions such as Parkinson disease has revolutionized management strategies. The pediatric population, however, can also be afflicted by functionally incapacitating neurological conditions that remain refractory despite the clinicians' best efforts. In such cases, DBS offers an additional treatment alternative. In this paper, the authors review their institution's experience with DBS in the pediatric population, and provide an overview of the literature on DBS in children. The authors conclude that DBS in children can and should be considered a valid and effective treatment option, albeit in highly specific and carefully selected cases.

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Section: Current Indications For Pediatric Dbsmentioning

confidence: 89%

Current and future indications for deep brain stimulation in pediatric populations

Lipsman¹,

Ellis²,

Lozano³

2010

FOC

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“…Moreover, in dystonic patients, cortical responses to 1Hz rTMS is unaffected by pre-conditionning with anodal TDCS contrarily to normal controls (179,181). In dystonia, there would be an increased tendency to form associations between sensory inputs and motor inputs which may lead to de-differentiation of motor representations in accordance with the theory of synaptic homeostatis (7,186,187).…”

Section: Plasticity In Dystonia: a Central Mechanismmentioning

confidence: 94%

“…The processing of sensory inputs is for instance altered either in the basal ganglia (187), the thalamus (124) and cerebral cortex (3).…”

Section: Plasticity In Dystonia: a Central Mechanismmentioning

confidence: 99%

Dystonia Pathophysiology: A Critical Review

Burbaud¹

2012

Dystonia - The Many Facets

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“…The procedure was similar to that performed for Parkinson disease [10,11] and dystonia [12] patients. Briefly, a Leksell stereotactic frame was fixed to the patient while under local anesthesia.…”

Section: Casesmentioning

confidence: 99%

Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease

Cabañés-Martínez

Pedro²,

Beorlegui³

et al. 2017

Stereotact Funct Neurosurg

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Background: It has been described that many Charcot-Marie-Tooth syndrome type 2 patients are affected by a very disabling type of tremor syndrome, the pathophysiology of which remains unclear. Deep brain stimulation (DBS) has been successfully applied to treat most types of tremors by implanting electrodes in the ventral intermediate nucleus of the thalamus (Vim). Methods: We used DBS applied to the Vim in 2 patients with severe axonal inherited polyneuropathies who developed a disabling tremor. Results: Both patients responded positively to stimulation, with a marked reduction of the tremor and with an improvement of their quality of life. Conclusion: We report 2 cases of tremor associated with a hereditary neuropathy with a good response to DBS.

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Deep brain stimulation in the globus pallidus to treat dystonia: Electrophysiological characteristics and 2 years’ follow-up in 10 patients

Cited by 50 publications

References 73 publications

Current and future indications for deep brain stimulation in pediatric populations

Current and future indications for deep brain stimulation in pediatric populations

Dystonia Pathophysiology: A Critical Review

Long-Term Effective Thalamic Deep Brain Stimulation for Neuropathic Tremor in Two Patients with Charcot-Marie-Tooth Disease

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