Deep Brain Stimulation in Patients with Parkinson's Disease: Effect on Psychiatric Symptoms and Quality of Life

Abstract

DBS of the STN in patients with PD is associated with an improvement in psychiatric (affective and sleep-wake cycle) symptoms, clinical motor symptoms, and quality of life at 1 year after surgery.

Impact of deep brain stimulation on quality of life and motor symptoms in Parkinson's disease and X-linked dystonia parkinsonism: The Philippine experience

“…Varied outcomes across PDQ-39 domains may be influenced by patient's age, disease duration and severity, co-morbidities, levodopa dose and pre-operative responsiveness, genetic predisposition and non-motor symptoms [18][19][20]. Vats et al concluded that age and QoL outcomes are not significantly related which was contradicted by Dafsari et al [17,21].…”

“…In the current study, all PD patients fell within this age group and showed significant improvement in all domains except emotional well-being and social support. Interestingly, current research on dystonia suggests that younger age at time of surgery is correlated with better motor symptoms, but not with functionality and QoL [18]. The EARLYTISM trial challenged the concept that disease severity should be disabling and refractory to medications before surgical interventions, suggesting early DBS in mild PD [3].…”

“…The EARLYTISM trial challenged the concept that disease severity should be disabling and refractory to medications before surgical interventions, suggesting early DBS in mild PD [3]. Likewise, early DBS has been recommended for less severe dystonia [18,20], allowing intervention before delayed appearance of disabling motor and non-motor symptoms. Non-motor symptoms (NMS) such as neuro-psychiatric and autonomic symptoms may strongly complicate QoL outcomes [22].…”

“…Once consent was obtained, multidisciplinary meetings were held. A total of eighteen [18] patients were recruited from 2017 to 2018 by convenience sampling.…”

“…Eighteen [18] individuals were initially identified for the study. Due to medical complications and issues with data completion, a total of thirteen [13] participants were included in the final analysis comprising of six [6] PD and seven [7] XDP patients (Table 1).…”