Deep brain stimulation in parkinson disease

Bernardo, Wanderley Marques; Rubira, Cláudio José; Silvinato, Antônio

doi:10.1590/1806-9282.65.4.541

Cited by 4 publications

(2 citation statements)

References 10 publications

(1 reference statement)

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“…DBS also increases the likelihood of risks such as suicide and hospital readmission with worsening of mobility or infection [ 54 ]. Progressive weight loss due to increased energy loss is seen in PD patients.…”

Section: Reviewmentioning

confidence: 99%

Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Shah¹,

Usman²,

Rehman³

et al. 2022

Cureus

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Parkinson's disease (PD) is a common progressive neurodegenerative movement disorder. The cardinal feature of Parkinson's is neuronal degeneration causing a dopamine deficit in the brain which leads to a host of clinical features in the patient. However, consensus over specific clinical criteria for diagnosis remains to be established. Parkinson's does not have a cure yet, but a variety of diagnostic and treatment protocols have been developed over the years with a primary focus on pharmacological therapy. Anti-parkinsonian drugs such as levodopa lose their efficacy over time and are needed in higher doses as the disease inevitably progresses. An alternative to pharmacological therapy is deep brain stimulation (DBS). Deep brain stimulation involves transcranial placement of unilateral or bilateral leads (wires) most commonly in the sub-thalamic nucleus or the globus pallidus interna of the brain by stereotactic surgery. Given the multiple hypotheses explaining the different effects of DBS with sometimes conflicting mechanisms, it is difficult to pinpoint the exact way in which DBS operates. Nevertheless, it has proven to be significantly effective. DBS, although being a cost-effective treatment measure for Parkinson's patients, is not without limitations. A careful selection of patients is required preoperatively that determines the response and tolerance to the therapy in patients. This review aims to summarize the current literature on DBS in Parkinson's with a focus on the hypothesized mechanisms, selection criteria, advantages and its limitations.

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Section: Reviewmentioning

confidence: 99%

Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Shah¹,

Usman²,

Rehman³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…A partir da combinação de imagens geradas por ressonância magnética (RNM) e tomografia computadorizada (TC), bem como do mapeamento intra operatório cerebral, é feita a localização anatômica dos núcleos almejados para refinar o máximo possível o alvo de implante do dispositivo de estimulação (BERNARDO WM, et al, 2019). A ECP é uma opção terapêutica bem estabelecida para o Mal de Parkinson, embora a sua eficácia ainda seja controversa (MANSOURI A, et al, 2018).…”

Section: Introductionunclassified

Análise da eficácia da estimulação cerebral profunda na doença de Parkinson

Varmes,

Tomás

et al. 2024

Acervo Médico

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Objetivo: Analisar se o local onde o dispositivo de ECP é inserido, interfere de maneira eficaz sobre as complicações da doença de Parkinson. Métodos: Foi realizada uma busca nas plataformas digitais BVS e PubMed com os descritores: doença de Parkinson e estimulação encefálica profunda. Os critérios de inclusão foram artigos completos, publicados nos últimos 6 anos (2016-2022), em inglês e do tipo estudo clínico controlado. Foram excluídos os artigos duplicados e os que fogem do tema abordado, resultando num total de 28 trabalhos. Resultados: Foi observado que as manifestações da DP (sejam elas motoras ou não motoras) foram melhoradas, em sua maioria, a partir da ECP. Efeitos adversos foram observados, que demandaram até a necessidade de troca do alvo terapêutico da ECP em alguns casos. A depressão foi um dos principais sintomas que não demonstrou melhora após o procedimento cirúrgico. Considerações finais: Deste modo, pode-se considerar que houve melhora dos sintomas motores e não motores em pacientes com doença de Parkinson, após estimulação cerebral profunda, as quais puderam demonstrar a eficácia do procedimento. O núcleo abordado que obteve maior eficácia foi o núcleo subtalâmico. Depressão e ansiedade não melhoraram após a ECP.

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The glutamatergic system in the development of stress-induced depression

Wei

2024

Annals of Medicine &Amp; Surgery

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Major depression is one of the most prevalent neuropsychological disorders and affects millions worldwide. In response, the monoaminergic system has been proposed to be one of the major focuses for conventional drugs in the treatment of depression, such as selective serotonin reuptake inhibitor (SSRI). Meanwhile, accumulating evidence suggests a paradigm shift from the monoamine system towards the glutamatergic system (Gerard Sanacora, Giulia Treccani, and Maurizio Popoli 2012) due to the long onset of the monoamine system targeting anti-depressant drugs. Both clinical and pre-clinical data support that glutamatergic system dysfunction were involved in the development of depression. Furthermore, therapeutic approaches that manipulating neuronal activity and N-methyl-D-aspartic acid (NMDA) receptor antagonist were shown to have profound effects in the treatment of depression. Here, I systematically reviewed our current understanding of the involvement of glutamatergic system dysregulation in the development of depression, which potentially could provide the mechanistic basis for future treatment development.

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Deep brain stimulation in parkinson disease

Abstract: The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.

Cited by 4 publications

References 10 publications

Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Análise da eficácia da estimulação cerebral profunda na doença de Parkinson

The glutamatergic system in the development of stress-induced depression

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