“…DBS is currently used as an effective treatment tool for a variety of neurological disorders (e.g., tremors and Parkinson's disease), and it has been extensively evaluated as a treatment for depression, albeit with less success. This special issue includes point-counterpoint articles by Holtzheimer et al 23 and Downar et al, 24 which weigh the strengths and weaknesses of pursuing ongoing efforts to evaluate DBS as a treatment for depression.…”