Deep brain stimulation in animal models of dystonia

Perl, Stefanie; Lüttig, Anika; Köhling, Rüdiger; Richter, Angelika

doi:10.1016/j.nbd.2022.105912

Cited by 5 publications

(6 citation statements)

References 128 publications

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“…Exploring various animal models of dystonia, researchers have employed DBS targeting the entopeduncular nucleus (EP), which serves as the rodent equivalent of the human GPi. The classical DBS approaches in rodent dystonia models have undergone extensive scrutiny in previous reviews [7,8]. One study utilized a genetically susceptible DYT-TOR1A rat model and induced dystonia-like movements in the hindlimbs through a peripheral nerve injury [38].…”

Section: Neuromodulation With Dbs In Dystonia Rodent Modelsmentioning

confidence: 99%

“…Lesioning of brain structures is a common approach in animal models to understand the role of specific brain regions in dystonia symptomatogenesis [4,5]. DBS in animal models is another method allowing for the modulation of brain nuclei and circuits, albeit with lack of specificity and an underlying mechanistic unclarity [6][7][8][9]. Allowing for a more cellspecific intervention of the motor circuit are now optogenetic and chemogenetic tools [10].…”

Section: Introductionmentioning

confidence: 99%

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Unraveling dystonia circuitry in rodent models using novel neuromodulation techniques

Rauschenberger,

2024

Dystonia

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Dystonia is a network disorder presumed to result from abnormalities in multiple brain regions and in multiple cell populations. The specific pathomechanisms affecting the motor circuits in dystonia are, however, still largely unclear. Animal models for dystonia have long been used to advance our understanding on how specific brain regions and cell populations are involved in dystonia symptomatogenesis. Lesioning, pharmacological modulation and electrical stimulation paradigms were able to highlight that both the basal ganglia and the cerebellum are pathologically altered in these animal models for dystonia. Techniques such as optogenetics and chemogenetics now offer the opportunity for targeted modulation of brain regions and most importantly cell populations and circuits. This could not only allow for a better understanding of the dystonic brain, but potentially improve and expand treatment options. In hopes that the insights from these neuromodulation techniques will eventually translate into therapies, we aim to summarize and critically discuss the findings from different in vivo approaches used to dissect the network dysfunctions underlying dystonia.

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Section: Neuromodulation With Dbs In Dystonia Rodent Modelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unraveling dystonia circuitry in rodent models using novel neuromodulation techniques

Rauschenberger,

2024

Dystonia

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“…There is evidence from clinical and experimental studies for abnormal synaptic plasticity and a prevailing in LTP, which lead to abnormal sensorimotor integration and consolidation of motor engrams [ 87 ]. The delayed effect of deep brain stimulation (DBS), which, in contrast to PD, could take several days, weeks, or even months, pointed out the abnormal plasticity that may be reorganised by the stimulation [ 10 , 44 , 49 , 63 , 84 , 94 , 124 ].…”

Section: Hypotheses For the Pathophysiology Of Isolated Dystoniamentioning

confidence: 99%

“…Such biomarker search studies cannot be performed on patients on a large scale and need to be flanked by experimental approaches. Thus, we need to uncover the pathophysiology of dystonia using animal models of dystonia [ 84 ].…”

Section: Deep Brain Stimulation In Dystoniamentioning

confidence: 99%

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Electrophysiological insights into deep brain stimulation of the network disorder dystonia

Franz,

Richter,

Köhling

2023

Pflugers Arch - Eur J Physiol

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Deep brain stimulation (DBS), a treatment for modulating the abnormal central neuronal circuitry, has become the standard of care nowadays and is sometimes the only option to reduce symptoms of movement disorders such as dystonia. However, on the one hand, there are still open questions regarding the pathomechanisms of dystonia and, on the other hand, the mechanisms of DBS on neuronal circuitry. That lack of knowledge limits the therapeutic effect and makes it hard to predict the outcome of DBS for individual dystonia patients. Finding electrophysiological biomarkers seems to be a promising option to enable adapted individualised DBS treatment. However, biomarker search studies cannot be conducted on patients on a large scale and experimental approaches with animal models of dystonia are needed. In this review, physiological findings of deep brain stimulation studies in humans and animal models of dystonia are summarised and the current pathophysiological concepts of dystonia are discussed.

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Deep brain stimulation and pallidotomy in primary Meige syndrome: a prospective cohort study

Hao,

Zheng,

Zhang

et al. 2024

Neurol Sci

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Deep brain stimulation in animal models of dystonia

Cited by 5 publications

References 128 publications

Unraveling dystonia circuitry in rodent models using novel neuromodulation techniques

Unraveling dystonia circuitry in rodent models using novel neuromodulation techniques

Electrophysiological insights into deep brain stimulation of the network disorder dystonia

Deep brain stimulation and pallidotomy in primary Meige syndrome: a prospective cohort study

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