Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

Wang, Min; Jia, Lina; XiaoBo, Wu; Sun, Zuoli; Xu, Zheng; Kong, Chao; Ma, Lin; Zhao, Renliang; Lu, Shibao

doi:10.1016/j.wneu.2020.05.029

Cited by 17 publications

(9 citation statements)

References 41 publications

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“…Subthalamic nucleus DBS induces the increase in BDNF to support the survival of the nigrostriatal system and promote the functionality of the basal ganglia-cortical circuitry in the parkinsonian brain ( Fischer et al, 2017 ; Fischer and Sortwell, 2019 ). In an animal model of spinal cord injury, DBS induces the protein expression of BDNF and improves the hind limb motor function ( Wang et al, 2020 ). Upregulation of PI3K/Akt/mammalian target of rapamycin (mTOR) has been reported to play a pivotal role in neuroprotection using pharmacological treatment ( Zhou et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

Wang

Wei

et al. 2021

Front. Aging Neurosci.

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Objective: Ischemic stroke is an important cause of death and disability worldwide. Early reperfusion by thrombolysis or thrombectomy has improved the outcome of acute ischemic stroke. However, the therapeutic window for reperfusion therapy is narrow, and adjuvant therapy for neuroprotection is demanded. Electrical stimulation (ES) has been reported to be neuroprotective in many neurological diseases. In this study, the neuroprotective effect of early somatosensory cortical ES in the acute stage of ischemia/reperfusion injury was evaluated.Methods: In this study, the rat model of transient middle cerebral artery occlusion was used to explore the neuroprotective effect and underlying mechanisms of direct primary somatosensory (S1) cortex ES with an electric current of 20 Hz, 2 ms biphasic pulse, 100 μA for 30 min, starting at 30 min after reperfusion.Results: These results showed that S1 cortical ES after reperfusion decreased infarction volume and improved functional outcome. The number of activated microglia, astrocytes, and cleaved caspase-3 positive neurons after ischemia/reperfusion injury were reduced, demonstrating that S1 cortical ES alleviates inflammation and apoptosis. Brain-derived neurotrophic factor (BDNF) and phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway were upregulated in the penumbra area, suggesting that BDNF/TrkB signals and their downstream PI3K/Akt signaling pathway play roles in ES-related neuroprotection.Conclusion: This study demonstrates that somatosensory cortical ES soon after reperfusion can attenuate ischemia/reperfusion injury and is a promising adjuvant therapy for thrombolytic treatment after acute ischemic stroke. Advanced techniques and devices for high-definition transcranial direct current stimulation still deserve further development in this regard.

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Section: Introductionmentioning

confidence: 99%

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

Wang

Wei

et al. 2021

Front. Aging Neurosci.

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“…Invasive approaches using epidural, cortical and deep brain stimulation are increasingly used to treat movement/neuropsychiatric disorders and epilepsy [22,51,52] and investigated to assist motor recovery following strokes and traumatic brain injuries [1,8,53]. Although the exact mechanisms underlying treatment effects using these invasive stimulation approaches are still largely unknown, neuroplastic changes are thought to play a significant role [13,14,54,55]. The goal of our study is to determine the most ideal stimulation parameters to induce cortical neuroplasticity in humans.…”

Section: Discussionmentioning

confidence: 99%

“…In DBS, the therapeutic effect is thought to be related to acutely enhancing or inhibiting activity in specific brain regions and until recently, less emphasis was placed on the potential contributing role of neural plasticity induced by electrical stimulation. Despite the important role of neural plasticity as part of the therapeutic effects in DBS [12][13][14], there is still much to learn about the most efficient plasticity inducing stimulation parameters using this approach [15].…”

Section: Introductionmentioning

confidence: 99%

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Herrero

Smith

Mishra

et al. 2021

Preprint

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The progress of therapeutic neuromodulation greatly depends on improving stimulation parameters to most efficiently induce neuroplasticity effects. Intermittent Theta Burst stimulation (iTBS), a form of electrical stimulation that mimics the natural brain activity patterns, has shown efficacy in inducing such effects in animal studies and rhythmic Transcranial Magnetic Stimulation (rTMS) studies in humans. However, little is known about the potential neuroplasticity effects of iTBS applied through intracranial electrodes in humans which could have implications for deep brain stimulation therapies. This study characterizes the physiological effects of cortical iTBS in the human cortex and compare them with single pulse alpha stimulation, another frequently used paradigm in rTMS research. We applied these stimulation paradigms to well-defined regions in the sensorimotor cortex which elicited contralateral hand or arm muscle contractions during electrical stimulation mapping in epilepsy patients implanted with intracranial electrodes. Treatment effects were evaluated using effective connectivity and beta oscillations coherence measures in areas connected to the treatment site as defined with cortico-cortical evoked potentials. Our results show that iTBS increases beta band synchronization within the sensorimotor network indicating a potential neuroplasticity effect. The effect is specific to the sensorimotor system, the beta frequency band and the stimulation pattern (no effect was found with single-pulse alpha stimulation). The effects outlasted the stimulation by three minutes. By characterizing the neurophysiological effects of iTBS within well-defined cortical networks, we hope to provide an electrophysiological framework that allows clinicians and researchers to optimize brain stimulation protocols which may have translational value.

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“…Several lines of research have shed light on its application for improving motor function after targeted stimulation of subcortical locomotor regions in rat SCI models ( Bachmann et al, 2013 , Hentall and Gonzalez, 2012 ). This effect appears to involve increased synaptic plasticity via enhancing BDNF synthesis and activation of tropomyosin-related kinase B (TrkB)–protein kinase B (PKB/Akt)–mammalian target of rapamycin (mTOR) pathway, which plays pivotal roles in neuronal survival as well as axonal growth and regeneration ( Kazim et al, 2021 , Wang et al, 2020 ).…”

Section: Neuromodulation-induced Neuroplasticitymentioning

confidence: 99%

Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury

Deep Brain Stimulation Improves Motor Function in Rats with Spinal Cord Injury by Increasing Synaptic Plasticity

Cited by 17 publications

References 41 publications

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates Ischemia/Reperfusion Injury of Rat Brain

Enhancing neuronal plasticity through intracranial theta burst stimulation in the human sensorimotor cortex

Corticospinal circuit neuroplasticity may involve silent synapses: Implications for functional recovery facilitated by neuromodulation after spinal cord injury

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