Deep brain stimulation for treatment-resistant depression: a safe and effective option

Torre, Domenico La; Torre, Attilio Della; Chirchiglia, Domenico; Volpentesta, Giorgio; Guzzi, Giusy; Lavano, Angelo

doi:10.1080/14737175.2020.1749049

Cited by 15 publications

(15 citation statements)

References 44 publications

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“…PET studies have demonstrated that negative affective states, including anxiety and depressive symptoms, are associated with abnormal regional metabolism in the rostral ACC (London et al, 2004), which could serve as an index for predicting eventual medication treatment response in major depression (Mayberg, 2002). In addition, our finding that the rostral ACC exhibited functional associations with affective symptoms in the MAs has also been reported in treatment-resistant depression patients (La Torre et al, 2020). This could possibly explain why no pharmacological approaches to date have been found to be effective in treating anxiety (Hellem, 2016) or depressive (Hellem et al, 2015) (Rusyniak, 2013).…”

Section: Affective Symptom Association With Brain Network Fc In Massupporting

confidence: 73%

Functional connectivity abnormalities underlying mood disturbances in male abstinent methamphetamine abusers

Jiang

Sun

Zhou

et al. 2021

Human Brain Mapping

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Anxiety and depression are the most common withdrawal symptoms of methamphetamine (METH) abuse, which further exacerbate relapse of METH abuse. To date, no effective pharmacotherapy exists for METH abuse and its withdrawal symptoms.Therefore, understanding the neuromechanism underlying METH abuse and its withdrawal symptoms is essential for developing clinical strategies and improving patient care. The aims of this study were to investigate brain network abnormalities in METH abusers (MAs) and their associations with affective symptoms. Forty-eight male abstinent MAs and 48 age-gender matched healthy controls were recruited and underwent resting state functional magnetic resonance imaging (fMRI). The severity of patient anxiety and depressive symptoms were measured by Hamilton anxiety and depression rating scales, which decreased across the duration of abstinence. Independent component analysis was used to investigate the brain network functional connectivity (FC) properties. Compared with healthy controls, MAs demonstrated hypo-intra-network FC in the cerebellar network and hyper-intra-network FC in the posterior salience network. A whole-brain regression analysis revealed that FC strength of clusters located in the right rostral anterior cingulate cortex (rACC) within the ventromedial network (VMN) was associated with affective symptoms in the patients. Importantly, the intra-network FC strength of the rACC in VMN mediated the association between abstinence duration and the severity level of affective symptoms. Our results demonstrate alterations in brain functional networks underlying Jing Li, Keith Kendrick, and Qiyong Gong contributed equally to the study.

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Section: Affective Symptom Association With Brain Network Fc In Massupporting

confidence: 73%

Functional connectivity abnormalities underlying mood disturbances in male abstinent methamphetamine abusers

Jiang

Sun

Zhou

et al. 2021

Human Brain Mapping

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“…Neuroimaging studies present functional locations which take part in development and maintenance of the symptoms of major depression. Studies conducted with use of DBS in depression treatment concentrate on seven main regions: subgenual anterior cingulate cortex (sACC), the ventral capsule/ventral striatum (VC/VS), the nucleus accumbens (NAcc), the lateral habenula (LHb), and the inferior thalamic peduncle (ITP), the medial forebrain bundle (MFB) and the bed nucleus of the stria terminalis (BNST) [8] [9].…”

Section: Description Of the State Of Knowledgementioning

confidence: 99%

Use of deep brain stimulation for treatment-resistant depression – review of main stimulation targets

TOKARZEWSKA

ORCZYK

OŁOWNIA

et al. 2023

J Educ Health Sport

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Deep brain stimulation (DBS) is an innovative method using neuromodulation in treatment of various diseases, most commonly used in Parkinson’s disease, tremor and dystonia. Due to method’s minimally invasive nature and very low incidence of severe adverse effects, the research upon its use in other indications is conducted. Treatment-resistant depression (TRD) is one of these emerging indications. Currently available data regarding the matter concentrate mainly of electrode placement within seven particular structures of the brain: the subgenual anterior cingulate cortex, the ventral capsule/ventral striatum, the lateral habenula, the nucleus accumbens, the inferior thalamic peduncle, the bed nucleus of the stria terminalis and the medial forebrain bundle. It is yet to be determined which stimulation targets bring the most optimal effect. Published clinical trials give basis to theorize that stimulation of each DBS target results in different neurotransmitter modulation. Antidepressant effects vary also depending on stimulation parameters and overall duration. The aim of this review is to compare various targets for stimulation and underlying physiological mechanisms in therapy of TRD. It is needed to keep in mind that there is still high demand on well-designed, randomized, double-blind trials on bigger groups of patients in order to exclude potential inconsistency between results of clinical research.

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“…Ponadto prowadzonych jest wiele badań nad skutecznością DBS w leczeniu m.in. choroby Alzheimera, choroby Huntingtona, zespołu Gillesa de la Tourette'a lub depresji [12][13][14][15] W związku z czym w przyszłości, lista zaburzeń, w których stosowanie DBS jako standard terapeutyczny, może ulec znacznemu wydłużeniu.…”

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Current state of knowledge concerning experimental applications for deep brain stimulation in specific neurologic and psychiatric disorders

Senger

Patrycja

KĘDZIORA-KORNATOWSKA

2022

J Educ Health Sport

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Introduction and objectives. Deep brain stimulation (DBS) is an invasive treatment method of certain neurologic and psychiatric disorders. It relies on sending external electrical stimulus to specific targets within the brain, causing change in their functioning. DBS is an approved management procedure, for instance in Parkinson’s Disease or Obsessive-compulsive disorder. Currently, studies are being conducted on the possible utilization of DBS in other disorders, especially exhibiting resistance for standard treatment. The objective of this study, is to present the state of knowledge concerning experimental usage of DBS in specific disorders. The following study is based on the review of scientific literature for the years 2000 – 2022. State of knowledge. Regarding experimental applications, DBS is being used among others in Tourette’s Syndrome, Huntington’s Disease, Depression and Alzheimer’s Disease. The review of the literature allows to gather data concerning initial patients selection, mechanism of action, potential benefits and thus far noted adverse effects. Evaluation of therapy efficacy is mostly limited, due to short observation periods and lack of unified patient qualification criteria for the operation. Conclusion. Deep brain stimulation is a management method, in many cases acknowledged as safe and efficient. It is observed to have a beneficial impact on the disorders described in the following article. However, the approval of DBS as a conventional treatment requires improvement of many factors decisive of therapeutic success. Conduction of more randomised clinical trials in the future, may be helpful in achieving this objective.

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Deep brain stimulation for treatment-resistant depression: a safe and effective option

Cited by 15 publications

References 44 publications

Functional connectivity abnormalities underlying mood disturbances in male abstinent methamphetamine abusers

Functional connectivity abnormalities underlying mood disturbances in male abstinent methamphetamine abusers

Use of deep brain stimulation for treatment-resistant depression – review of main stimulation targets

Current state of knowledge concerning experimental applications for deep brain stimulation in specific neurologic and psychiatric disorders

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