Deep brain stimulation for patients with Parkinson's disease: Effect on caregiver burden

Crespo-Burillo, J.A.; Rivero-Celada, David; Cabezón, A. Saenz-de; Casado-Pellejero, J.; Alberdi-Viñas, Juan; Alarcia-Alejos, R.

doi:10.1016/j.nrleng.2016.05.012

Cited by 10 publications

(17 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A good caregiver support system is crucial in PD management [6,7]. Caregiver burden has been studied previously in PD, both in the general PD population [6][7][8][9], and with specific regard to DBS patients [10][11][12][13][14][15]. Caregiver burden was reported similar in both the general PD population, and in caregivers of DBS patients [10].…”

Section: Introductionmentioning

confidence: 94%

“…Six studies reported data on caregiver burden (Table 2) [10][11][12][13][14][15]. Caregiver burden after STN DBS was relieved in one study [14], unchanged in four studies [10][11][12][13][14], and not reported in one study [15]. One study found no significant linear difference between Zarit Burden Inventory (ZBI) scores at baseline and one year follow-up (i.e.…”

Section: Caregiver Burdenmentioning

confidence: 99%

“…Caregiver burden has been studied previously in PD, both in the general PD population [6][7][8][9], and with specific regard to DBS patients [10][11][12][13][14][15]. Caregiver burden was reported similar in both the general PD population, and in caregivers of DBS patients [10]. Severity of PD symptoms, psychological distress and disabilities negatively impacts both QoL and burden in caregivers of PD patients [16,17].…”

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Effect of deep brain stimulation on caregivers of patients with Parkinson's disease: A systematic review

Hienen

Contarino

Middelkoop

et al. 2020

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

Background: Caregivers of patients with Parkinson's Disease (PD) often provide important support in the pre-and postoperative phase of Deep Brain Stimulation (DBS). DBS-associated changes of patient-functioning may affect caregiver wellbeing and impact the support system. Factors influencing caregiver-wellbeing under these circumstances are incompletely known. Objective: to systematically review studies of sufficient methodological quality on the impact of DBS on caregivers of PD patients. Methods: using PRISMA guidelines, major databases were searched up to May 2020. Five subcategories were identified: Caregiver burden, Caregiver cognitive and psychiatric functioning, Caregiver Quality of Life (QoL), Marital Satisfaction/Conflicts, and Caregiver Satisfaction. Quality was assessed using an in-house checklist. Results: 293 studies were identified; 12 were ultimately included. Caregiver burden, psychiatric and cognitive functioning and QoL remained relatively unchanged. Results on marital satisfaction/conflicts were contrasting: an increase in marital conflicts despite improved relationship quality scores DBS. Caregiver satisfaction with surgery was low with 50-58% of caregivers being disappointed with DBS outcomes. Concerning caregiver related factors: a higher preoperative caregiver QoL, younger age, lower scores on psychiatric rating scales, and more favourable preoperative relationship quality scores, were associated with better caregiver wellbeing. A favourable patient-profile includes younger age and age-at-onset, shorter disease duration, lower medication requirements, and lower scores on psychiatric rating scales. Conclusion: Although most patient-and caregiver-related subdomains remained unchanged after DBS, dissatisfaction among caregivers and marital problems may constitute a large risk for a well-functioning patient-caregiver dyad. Early recognition of potential problem situations may improve post-DBS care for both patients and caregivers.

show abstract

Section: Introductionmentioning

confidence: 94%

Section: Caregiver Burdenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Effect of deep brain stimulation on caregivers of patients with Parkinson's disease: A systematic review

Hienen

Contarino

Middelkoop

et al. 2020

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

show abstract

“…Hinsichtlich der Bedeutung medikamentöser und invasiver Therapien auf die Betreuungsbelastung finden sich in der Literatur einerseits der Faktor Dosis der dopaminergen Therapie als Ausdruck der Krankheitsdauer und des Schweregrades der motorischen Symptomatik des Pfleglings als ein Belastungsfaktor [12,33,[35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50], andererseits einige medikamentöse Therapien, wie die Levodopa/Carbidopa intestinale Geltherapie (Duodopa), zu der in nichtkontrollierten Studien teilweise positive Effekte auf die Betreuungsbelastung festgestellt wurden [38,39] und die Palliativ-Betreuung [19,20,32]. Außerdem wurde in kontrollierten Therapiestudien mit Memantin und Donepezil bei Personen mit Parkinson-Demenz und Demenz mit Lewy-Körperchen sowie mit Rivastigmin bei apathischen depressions-und demenzfreien Parkinson-Pat.…”

Section: Literaturrecherche Und Analyseunclassified

“…Die tiefe Hirnstimulation kann zwar die Lebensqualität von Pat. verbessern, Belastungen für Betreuungspersonen scheinen sich laut jüngeren Studien aber nicht reduzieren lassen [40][41][42]45]. Neurokognitive Beeinträchtigungen [34,[52][53][54][55] Neuropsychiatrische Symptome, wie Depression, Angst, Apathie, Mangel an Empathie, Aggression, Halluzinationen und Impuls-Kontrollstörungen [15,33,[55][56][57][58][59][60] Nächtliche Symptome, inklusive Pollakisurie und Inkontinenz [61,62] Schlafstörungen [15,36] Autonome Störungen (z.B.…”

Section: Literaturrecherche Und Analyseunclassified

Belastungen in der Betreuung von Parkinson-Patientinnen und - Patienten

Ransmayr¹

2020

Fortschr Neurol Psychiatr

View full text Add to dashboard Cite

ZusammenfassungPatientinnen und Patienten (Pat.) mit Parkinson-Krankheit bedürfen mit zunehmender Krankheitsdauer und Schweregrad persönlicher Betreuung, die meist von weiblichen Angehörigen gewährleistet wird. Die Belastungen für pflegende Angehörige resultieren einerseits aus den motorischen Beeinträchtigungen der Pat., andererseits von neurokognitiven und neuropsychiatrischen Symptomen sowie Verhaltensstörungen, Störungen des autonomen Nervensystems, der Miktion, des Schlafes und der Selbstständigkeit. Gesundheitliche Probleme der Betreuungsperson, u. a. Depression und Angst, emotionale Probleme mit dem Pflegling, Beeinträchtigung des Schlafs, sowie Einschränkungen in persönlichen Anliegen, Beruf, Familie, Freizeitgestaltung, sozialen Aktivitäten, finanzielle Einbußen und mangelhafte soziale Unterstützung stellen weitere Belastungsfaktoren dar. Personen mit dem Risiko einer erheblichen Betreuungsbelastung sind frühzeitig zu identifizieren, um ihnen Informationen über die Krankheit und Unterstützungsmöglichkeiten sowie entsprechende personelle, psychologische und finanzielle Unterstützung zukommen zu lassen.

show abstract

Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson’s disease

Valldeoriola¹,

Catalán

Escamilla-Sevilla³

et al. 2021

npj Parkinsons Dis.

View full text Add to dashboard Cite

Levodopa-carbidopa intestinal gel (LCIG) has shown to be efficacious in motor and non-motor symptoms (NMS). Nevertheless, studies with patient Quality of Life (QoL) as a primary endpoint are scarce. To assess the effect of LCIG on Advanced Parkinson’s Disease (APD) patients QoL. Secondarily, the impact on motor symptoms and NMS, emotional well-being, treatment satisfaction, and caregiver QoL, stress, disease burden, anxiety, depression, and work impairment were also investigated. In this prospective, 6-month multicenter postmarketing observational study, LCIG was administered to 59 patients with APD. Endpoints were assessed using validated scales and questionnaires. LCIG significantly improved patient QoL (PDQ-39 mean change ± standard deviation from baseline, −12.8 ± 14.6; P < 0.0001), motor symptoms (UPDRS-III in “On,” −6.5 ± 11.8; P = 0.0002), NMS (NMSS, −35.7 ± 31.1; P < 0.0001), mood (Norris/Bond-Lader VAS, −6.6 ± 21.1; P = 0.0297), fatigue (PFS-16, −0.6 ± 1.0; P = 0.0003), depression (BDI-II, −5.1 ± 9.4; P = 0.0002), anxiety (BAI, −6.2 ± 9.6; P < 0.0001), and patient treatment satisfaction (SATMED-Q, 16.1 ± 16.8; P < 0.0001). There were significant correlations between the change from baseline to 6 months between PDQ-39 and UPDRS-IV, NMSS, BAI, BDI-II, AS, and PFS-16 scores, and Norris/Bond-Lader alertness/sedation factor. Caregiver anxiety also improved (Goldberg anxiety scale, −1.1 ± 1.0; P = 0.0234), but the clinical relevance of this finding is questionable. The serious adverse events reported were similar to those previously described for LCIG. In patients with APD, LCIG improves QoL, motor symptoms and NMS, emotional well-being, and satisfaction with the treatment. Improvement in patient QoL is associated with improvements in motor complications, NMS, anxiety, depression, apathy and fatigue. Improvements in patients’ QoL does not correspond with improvements in caregivers’ QoL or burden.

show abstract

Deep brain stimulation for patients with Parkinson's disease: Effect on caregiver burden

Cited by 10 publications

References 20 publications

Effect of deep brain stimulation on caregivers of patients with Parkinson's disease: A systematic review

Effect of deep brain stimulation on caregivers of patients with Parkinson's disease: A systematic review

Belastungen in der Betreuung von Parkinson-Patientinnen und - Patienten

Patient and caregiver outcomes with levodopa-carbidopa intestinal gel in advanced Parkinson’s disease

Contact Info

Product

Resources

About