Deep brain stimulation for obsessive–compulsive disorder: a systematic review and meta-analysis

Kisely, Steve; Hall, Katharine E.; Siskind, Dan; Frater, Julanne; Olson, Sven R.; Crompton, David

doi:10.1017/s0033291714000981

Cited by 81 publications

(61 citation statements)

References 33 publications

(92 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nangunoori et al (2013) performed a pooled analysis based on the statement that there are scarce DBS randomized clinical trials, and intended to gather a larger number of subjects reported individually or in case series [37]. Kisely et al (2014) chose to perform a meta-analysis of sham-controlled randomized clinical trials [50]. Therefore, while the first review included a larger number of studies, the second evaluated studies with a more consistent design.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes

Senço

Huang

D’Urso

et al. 2015

Expert Review of Medical Devices

View full text Add to dashboard Cite

Background Neuromodulation techniques for obsessive–compulsive disorder (OCD) treatment have expanded with greater understanding of the brain circuits involved. Transcranial direct current stimulation (tDCS) might be a potential new treatment for OCD, although the optimal montage is unclear. Objective To perform a systematic review on meta-analyses of repetitive transcranianal magnetic stimulation (rTMS) and deep brain stimulation (DBS) trials for OCD, aiming to identify brain stimulation targets for future tDCS trials and to support the empirical evidence with computer head modeling analysis. Methods Systematic reviews of rTMS and DBS trials on OCD in Pubmed/MEDLINE were searched. For the tDCS computational analysis, we employed head models with the goal of optimally targeting current delivery to structures of interest. Results Only three references matched our eligibility criteria. We simulated four different electrodes montages and analyzed current direction and intensity. Conclusion Although DBS, rTMS and tDCS are not directly comparable and our theoretical model, based on DBS and rTMS targets, needs empirical validation, we found that the tDCS montage with the cathode over the pre-supplementary motor area and extra-cephalic anode seems to activate most of the areas related to OCD.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Kisely et al (2014) performed a meta-analysis to evaluate DBS effects on major depressive disorder, anorexia and OCD [50]. Due to the inclusion and exclusion criteria for the clinical trials, they only evaluated five OCD trials [40,48,49,51,52].…”

Section: Resultsmentioning

confidence: 99%

Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes

Senço

Huang

D’Urso

et al. 2015

Expert Review of Medical Devices

View full text Add to dashboard Cite

show abstract

“…Similarly, a meta-analysis that included 10 studies with 64 OCD patients reported some heterogeneity in the response, but an overall significant clinical improvement, with a 2.77 SP reduction in Y-BOCS score [10]. Another meta-analysis also shows a partial symptom remission (mean Y-BOCS reduction of 9 points), but no significant impact in comorbid anxiety or depression [11].…”

Section: Dbs In Ocdmentioning

confidence: 93%

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

Andrade¹,

Mota²,

Ferreira³

et al. 2017

IJCNMH

View full text Add to dashboard Cite

The potential therapeutic value of electricity to treat neuropsychiatric disorders has been known for a long time. However, it is only recently that it has been successfully applied to these clinical conditions. Two of the most promising neuromodulation techniques are the deep brain stimulation (DBS) and the transcranial magnetic stimulation (TMS). DBS uses a high-frequency stimulation that causes a "reversible lesion" and is increasingly becoming an alternative for lesional surgery for its better balance between efficacy, tolerability and safety, and has consistently been shown to improve depressive and obsessive symptoms. TMS is a non-invasive and safe approach that has been approved for the treatment of major depressive disorder and for auditory-verbal hallucinations in schizophrenia and is being studied in several other psychiatric disorders, such as obsessive-compulsive disorder, eating disorders and negative symptoms of schizophrenia.In the current paper, we will review recent evidence of these two neuromodulation techniques, its main psychiatric indications and present two brief case reports to further illustrate its clinical applicability.

show abstract

“…DBS for epilepsy 232 DBS was found to decrease seizure frequencies in patients with 233 medically refractory epilepsy (Fisher et al, 2010;Fridley et al, 234 2012;Morrell, 2011;Sprengers et al, 2014). Based on the imaging studies, the subgenual cingulate area 261 (Brodmann area 25 or Cg25) was shown to be an important nodal 262 point in limbic-cortical circuit in depression with increased 263 metabolic rate and cerebral blood flow in depressed patients 264 (Mayberg et al, 2000;Seminowicz et al, 2004 Kisely et al, 2014). It was postulated that the 285 clinical improvement was achieved by normalizing the dysfunc-286 tional orbitofrontal circuits (Bourne et al, 2012) and by increasing 287 thalamocortical inhibition (Lozano and Lipsman, 2013).…”

Section: Essential Tremor 221mentioning

confidence: 99%

The mechanisms of action of deep brain stimulation and ideas for the future development

Udupa

Chen

2015

Progress in Neurobiology

127

133

View full text Add to dashboard Cite

Deep brain stimulation for obsessive–compulsive disorder: a systematic review and meta-analysis

Abstract: DBS may show promise for treatment-resistant OCD but there are insufficient randomized controlled data for other psychiatric conditions. DBS remains an experimental treatment in adults for severe, medically refractory conditions until further data are available.

Cited by 81 publications

References 33 publications

Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes

Transcranial direct current stimulation in obsessive–compulsive disorder: emerging clinical evidence and considerations for optimal montage of electrodes

Neuromodulation in Psychiatric disorders: recent findings and clinical implications

The mechanisms of action of deep brain stimulation and ideas for the future development

Contact Info

Product

Resources

About