Deep Brain Stimulation for Movement Disorders

Pizzolato, Gilberto; Mandat, Tomasz

doi:10.3389/fnint.2012.00002

Cited by 55 publications

(49 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Interest in the GPi within the context of Parkinson's disease arises from many sources, including the therapeutic effects exerted from lesioning (pallidotomy) or DBS at this target (Follett and Torres-Russotto, 2012;Obeso et al, 2001;Pizzolato and Mandat, 2012;Rouaud et al, 2010). In classical models of Parkinson's disease, loss of striatal dopamine is predicted to result in hyperactivity within the GPi with consequent over-inhibition of thalamocortical motor relays (Obeso et al, 2008b;Wichmann et al, 2011).…”

Section: Internal Globus Pallidusmentioning

confidence: 99%

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

Albaugh

Shih²

2013

Brain Connectivity

View full text Add to dashboard Cite

Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) represents a powerful clinical tool for the alleviation of many motor symptoms that are associated with Parkinson's disease. Despite its extensive use, the underlying therapeutic mechanisms of STN-DBS remain poorly understood. In the present review, we integrate and discuss recent literature examining the network effects of STN-DBS for Parkinson's disease, placing emphasis on neuroimaging findings, including functional magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography. These techniques enable the noninvasive detection of brain regions that are modulated by DBS on a whole-brain scale, representing a key experimental strength given the diffuse and far-reaching effects of electrical field stimulation. By examining these data in the context of multiple hypotheses of DBS action, generally developed through clinical and physiological observations, we define a multitude of consistencies and inconsistencies in the developing literature of this rapidly moving field.

show abstract

Section: Internal Globus Pallidusmentioning

confidence: 99%

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

Albaugh

Shih²

2013

Brain Connectivity

View full text Add to dashboard Cite

show abstract

“…Electrical stimulation of discrete brain areas is a clinically increasingly used symptomatic treatment for neurological movement and affective disorders (Schlapfer and Bewernick, 2009; Pizzolato and Mandat, 2012). To further improve this treatment, the necessity arises to optimize the brain-device-interface on the cellular scale (Martens et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A simple implantation method for flexible, multisite microelectrodes into rat brains

Richter¹,

Xie²,

Schumacher³

et al. 2013

Front. Neuroeng.

View full text Add to dashboard Cite

A long term functional and reliable coupling between neural tissue and implanted microelectrodes is the key issue in acquiring neural electrophysiological signals or therapeutically excite neural tissue. The currently often used rigid micro-electrodes are thought to cause a severe foreign body reaction resulting in a thick glial scar and consequently a poor tissue-electrode coupling in the chronic phase. We hypothesize, that this adverse effect might be remedied by probes compliant to the soft brain tissue, i.e., replacing rigid electrodes by flexible ones. Unfortunately, this flexibility comes at the price of a low stiffness, which makes targeted low trauma implantation very challenging. In this study, we demonstrate an adaptable and simple method to implant extremely flexible microprobes even to deep areas of rat's brain. Implantation of flexible probes is achieved by rod supported stereotactic insertion fostered by a hydrogel (2% agarose in PBS) cushion on the exposed skull. We were thus able to implant very flexible micro-probes in 70 rats as deep as the rodent's subthalamic nucleus. This work describes in detail the procedures and steps needed for minimal invasive, but reliable implantation of flexible probes.

show abstract

“…For instance, deep brain stimulation (DBS), optogenetics analysis and human pluripotent stem cells could potentially be used as therapies, disease models, or in drug screening assays. Of all of the aforementioned therapies, DBS in particular, has become an alternative treatment for patients who no longer respond to L-DOPA administration (Pizzolato and Mandat, 2012).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

Fraley

Forbes

et al. 2012

Neuroscience

View full text Add to dashboard Cite

Deep Brain Stimulation for Movement Disorders

Cited by 55 publications

References 47 publications

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

Neural Circuit Modulation During Deep Brain Stimulation at the Subthalamic Nucleus for Parkinson's Disease: What Have We Learned from Neuroimaging Studies?

A simple implantation method for flexible, multisite microelectrodes into rat brains

Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation

Contact Info

Product

Resources

About