Deep brain stimulation for chronic pain

Boccard, Sandra; Pereira, Erlick A. C.; Aziz, Tipu Z.

doi:10.1016/j.jocn.2015.04.005

Cited by 124 publications

(87 citation statements)

References 111 publications

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“…Current theory broadly postulates that DBS modulates fiber pathways in the pain network in order to treat chronic pain, although the exact mechanism is not understood [2,21,43,44,45,46]. DBS of the nucleus accumbens (NAcc) in control rats prompted a decreased metabolism in the basal ganglia and periaqueductal gray, while metabolism increased in the subiculum [47].…”

Section: Methodsmentioning

confidence: 99%

“…It is currently believed to constitute components of the lateral pain system, and as such the area became a major target of interest in the earliest studies of DBS for DRS [38,43,44,45]. Contemporary practice is to specifically target the VPM for facial pain, while the VPL can be a target for arm and leg pain [45].…”

Section: Methodsmentioning

confidence: 99%

“…Studies have shown increased PAG activity in patients experiencing allodynia [18]. While stimulation of the PAG/PVG has had some clinical success in the treatment of neuropathic pain, it is generally recommended only if there is at least a nociceptive component [11,42,45,52,62]. …”

Section: Methodsmentioning

confidence: 99%

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Deep Brain Stimulation for the Treatment of Dejerine-Roussy Syndrome

Ward

Mammis²

2017

Stereotact Funct Neurosurg

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Background/Aims: Patients who suffer from Dejerine-Roussy syndrome commonly experience severe poststroke hemibody pain which has historically been attributed to thalamic lesions. Despite pharmacological treatment, a significant proportion of the population is resistant to traditional therapy. Deep brain stimulation is often appropriate for the treatment of resistant populations. In this review we aim to summarize the targets that are used to treat Dejerine-Roussy syndrome and provide insight into their clinical efficacy. Methods: In reviewing the literature, we defined stimulation success as achievement of a minimum of 50% pain relief. Results: Contemporary targets for deep brain stimulation are the ventral posterior medial/ventral posterior lateral thalamic nuclei, periaqueductal/periventricular gray matter, the ventral striatum/anterior limb of the internal capsule, left centromedian thalamic nuclei, the nucleus ventrocaudalis parvocellularis internis, and the posterior limb of the internal capsule. Conclusions: Due to technological advancements in deep brain stimulation, its therapeutic effects must be reevaluated. Despite a lack of controlled evidence, deep brain stimulation has been effectively used as a therapeutic in clinical pain management. Further clinical investigation is needed to definitively evaluate the therapeutic efficacy of deep brain stimulation in treating the drug-resistant patient population.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Deep Brain Stimulation for the Treatment of Dejerine-Roussy Syndrome

Ward

Mammis²

2017

Stereotact Funct Neurosurg

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“…While we applied our ICA-MI-based approach to Parkinson's disease patients here, it is also suitable for cleaning data recorded from patients who undergo DBS for other reasons such as chronic and phantom pain (Boccard et al, 2015) or even beyond that, to other brain stimulation therapies such as vagal nerve stimulation (Groves and Brown, 2005) or when combining MEG and transcranial electric stimulation (Soekadar et al, 2013). In addition, the present ICA-MIbased artefact removal can readily be extended to remove other kinds of artefacts, such as cardio-ballistic or eye blink artefacts.…”

Section: Observations Recommendations and Outlookmentioning

confidence: 99%

Rejecting deep brain stimulation artefacts from MEG data using ICA and mutual information

Abbasi

Hirschmann

Schmitz

et al. 2016

Journal of Neuroscience Methods

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“…The use of DBS is also being explored in a wide range of neurodisorders including relief from severe psychiatric illness (21) and pain, such as cluster headaches. (24) During stereotactic and functional neurosurgery, the target region is often positioned in the deep brain and therefore not able to be reached with open surgery. Therefore, a navigation system for precise and safe intervention towards the specific brain target is required.…”

Section: Introductionmentioning

confidence: 99%

Optical Monitoring Techniques for Navigation during Stereotactic Neurosurgery

2016

Sensors and Materials

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Optical techniques are becoming increasingly important in healthcare, as both therapeutic and diagnostic tools. In neurosurgery, photonic technologies such as the microscope have already found widespread use. The overall aim of this paper is to give an overview of optical monitoring methods and their implementation and use in stereotactic and functional neurosurgery. The development steps presented in this paper range from radiofrequency-lesion size estimation using optics to a system adapted for neurosurgical intraoperative navigation during stereotactic deep brain stimulation (DBS) lead implantations. The two main optical methods implemented as intraoperative guidance tools are laser Doppler flowmetry and diffuse reflectance spectroscopy. By combining these fundamental methods with probe designs adapted to stereotactic systems, vessels can be tracked and "bar-codes" of tissue type along pre-defined trajectories used for DBS implantations identified. Examples of the optical methods used in relation to stereotactic DBS implantations are given.

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Deep brain stimulation for chronic pain

Cited by 124 publications

References 111 publications

Deep Brain Stimulation for the Treatment of Dejerine-Roussy Syndrome

Deep Brain Stimulation for the Treatment of Dejerine-Roussy Syndrome

Rejecting deep brain stimulation artefacts from MEG data using ICA and mutual information

Optical Monitoring Techniques for Navigation during Stereotactic Neurosurgery

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