Deep-brain-stimulation does not impair deglutition in Parkinson's disease

Lengerer, Sabrina; Kipping, Judy; Rommel, Natalie; Weiß, Daniel; Breit, Sorin; Gasser, Thomas; Plewnia, Christian; Krüger, Rejko; Wächter, Tobias

doi:10.1016/j.parkreldis.2012.04.014

Cited by 40 publications

(47 citation statements)

References 21 publications

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“…Lengerer and colleagues [26] conducted a retrospective study of swallowing function in 18 participants with PD. Pre-DBS assessments were completed “on” medication.…”

Section: Experimental Studiesmentioning

confidence: 99%

Swallowing and deep brain stimulation in Parkinson's disease: A systematic review

Troche

Brandimore

Foote

et al. 2013

Parkinsonism & Related Disorders

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The purpose of this review is to assess the current state of the literature on the topic of deep brain stimulation (DBS) and its effects on swallowing function in Parkinson’s disease (PD). Pubmed, Cochrane review, and web of science searches were completed on all articles addressing DBS that contained a swallowing outcome measure. Outcome measures included the penetration/aspiration scale, pharyngeal transit time, oropharyngeal residue, drooling, aspiration pneumonia, death, hyolaryngeal excursion, epiglottic inversion, UPDRS scores, and presence of coughing/throat clearing during meals. The search identified 13 studies specifically addressing the effects of DBS on swallowing. Critical assessment of the 13 identified peer-reviewed publications revealed nine studies employing an experimental design, (e.g. “on” vs. “off”, pre- vs. post-DBS) and four case reports. None of the nine experimental studies were found to identify clinically significant improvement or decline in swallowing function with DBS. Despite these findings, several common threads were identified across experimental studies and will be examined in this review. Additionally, available data demonstrate that, although subthalamic nucleus (STN) stimulation has been considered to cause more impairment to swallowing function than globus pallidus internus (GPi) stimulation, there are no experimental studies directly comparing swallowing function in STN vs. GPi. Moreover, there has been no comparison of unilateral vs. bilateral DBS surgery and the coincident effects on swallowing function. This review includes a critical analysis of all experimental studies and discusses methodological issues that should be addressed in future studies.

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“…Lengerer and colleagues [26] conducted a retrospective study of swallowing function in 18 participants with PD. Pre-DBS assessments were completed “on” medication.…”

Section: Experimental Studiesmentioning

confidence: 99%

Swallowing and deep brain stimulation in Parkinson's disease: A systematic review

Troche

Brandimore

Foote

et al. 2013

Parkinsonism & Related Disorders

View full text Add to dashboard Cite

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“…In cases where drug treatment is complicated by incapacitating response fluctuations, deep brain stimulation is required -a surgical approach where electrodes are placed in the basal ganglia, most often in the subthalamic nucleus. With the exception of one case study, in which symptoms of stridor, dysphagia and aspiration were resolved when the subthalamic nucleus stimulator was switched off [58], studies have either reported no clinically relevant changes in deglutition after subthalamic nucleus deep brain stimulation [59] or an improvement of dysphagia in the 'on' condition [60][61][62], in particular in the pharyngeal stages of swallowing [63].…”

Section: Medical Treatmentmentioning

confidence: 98%

Management of Dysphagia and Drooling in Patients With Parkinson’s Disease

2013

Neurodegen. Dis. Manage.

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SUMMARY Dysphagia and drooling are frequently reported consequences of Parkinson’s disease (PD) and this article aims to review their management. Several PD-specific and validated instruments are available for the screening and evaluation of dysphagia and drooling, including the Swallowing Disturbance Questionnaire (SDQ), Sialorrhea Clinical Scale for Parkinson’s disease (SCS-PD), Radboud Oral Motor Inventory for Parkinson’s Disease (ROMP), subscales for swallowing and saliva, and non-motor questionnaires that include items on dysphagia and drooling (e.g., Scales for Outcomes in Parkinson’s disease-Autonomic [SCOPA-AUT]; Non-motor Symptoms Questionnaire for Parkinson’s disease [PD-NMSQuest]; and Non-motor Symptoms Assessment Scale for Parkinson’s disease [NMSS]). For the behavioral treatment of dysphagia traditional techniques are helpful, however, exercise training might be more effective. Dysphagia appears to be resistant to drug treatment, but dysphagic patients may benefit from deep brain stimulation. For the treatment of drooling, swallow compensations should be tried, but when saliva reduction is required, botulinum-toxin injections are currently the best option. Overall, there is an urgent need for new approaches to treat dysphagia and drooling in PD.

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“…However, we do not have scientific evidences of the benefits of this approach [56] thus, studies are reinforced. More recently, studies discuss the transcranial magnetic stimulation in cerebral cortex [16] neuromuscular electrical stimulation [39] deepbrain-stimulations in subthalamics nucleus [57,58] and surface electrical stimulation in sub mental region [59]. To date, none of these studies reported a significant improvement of swallowing with only one type of stimulation.…”

Section: Management Of Dysphagia In Pdmentioning

confidence: 99%

Dysphagia in Parkinson’s disease: Prevalence, Impact and Management Challenges

Luchesi¹,

Toledo²,

Mourão³

2017

JOENTR

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The aim of this review is to present an update of the prevalence, impact and management challenges of dysphagia in Parkinson's disease. In the last 5 years, the prevalence of dysphagia in Parkinson's disease (PD) has been reported with a wide range of values in the literature. The dysphagia prevalence ranged from 11% to 100% of the patients with PD. This variation, generally, depended on the disease stage and the procedure of swallowing assessment. In the management of dysphagia, compensatory techniques, rehabilitation exercises and deep-brain stimulation have been conducted. Despite of the lack of high scientific evidences of efficiency of the majority of these interventions, the positive aspects and benefits are described in the actual literature. Moreover, this review paper discuss about the importance of the dysphagia assessment and treatment in the best timing to prevent complications, as pulmonary and nutritional impairment, and to improve quality of life.

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Deep-brain-stimulation does not impair deglutition in Parkinson's disease

Cited by 40 publications

References 21 publications

Swallowing and deep brain stimulation in Parkinson's disease: A systematic review

Swallowing and deep brain stimulation in Parkinson's disease: A systematic review

Management of Dysphagia and Drooling in Patients With Parkinson’s Disease

Dysphagia in Parkinson’s disease: Prevalence, Impact and Management Challenges

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