Deep Brain Stimulation and Thalamotomy for the Treatment of Dystonia
                        Acquired by Moyamoya Disease with Stroke

Wu, Yunhao; Su, Daoqing; Wang, Yunhan; Li, Hongxia; Zhang, Chencheng; Sun, Bomin; Li, Dianyou; Wu, Yiwen

doi:10.5334/tohm.73

Cited by 2 publications

(2 citation statements)

References 16 publications

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“…Stimulation of the central nervous system—including epidural stimulation over motor cortex, 19 vagus nerve stimulation, 20 and deep brain stimulation (DBS) of the cerebellum 21 —appears to promote functional recovery of arm function after stroke (Figure 3). DBS may also relieve post‐stroke dystonia 22 or pain 23,24 . Although the electrical stimulation of various brain targets may be timed to coincide with rehabilitation therapies, the fixed parameters are not “closed loop.” This is important because, as has been known for over a century, electrical stimulation—delivered with identical parameters at the identical anatomical target in the brain—can induce dramatically different effects, whether it be for causing a particular physical movement 25 or inducing an internal mental state 26 .…”

Section: Stimulation Of the Brain To Enhance Motor Plasticity And Rec...mentioning

confidence: 99%

“…18 Stimulation of the central nervous system-including epidural stimulation over motor cortex, 19 vagus nerve stimulation, 20 and deep brain stimulation (DBS) of the cerebellum 21 -appears to promote functional recovery of arm function after stroke (Figure 3). DBS may also relieve post-stroke dystonia 22 or pain. 23,24 Although the electrical stimulation of various brain targets may be timed to coincide with rehabilitation therapies, the fixed parameters are not "closed loop."…”

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confidence: 99%

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An artificial nervous system to treat chronic stroke

Serruya

Rosenwasser

2021

Artificial Organs

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Despite remarkable advances in the treatment of numerous medical conditions, neurological disease and injury remains an outstanding challenge and cause of disability worldwide. The decreased regenerative capacity and extreme complexity and heterogeneity of nervous tissue, in particular the brain, and the fact that the brain remains the least understood organ, have hampered our ability to provide definitive treatments for prevalent conditions such as stroke. Stroke is the second-leading cause of death worldwide, and the nervous system is intimately involved in other prevalent conditions including ischemic heart disease, diabetes mellitus, and hypertension. Advances in neuromodulation, electroceuticals, microsurgical techniques, optogenetics, braincomputer interfaces, and autologous constructs offer potential solutions to address the otherwise permanent neurological deficits of stroke and other conditions. Here we review these various approaches to build an "artificial nervous system" that could restore function and independence in people living with these conditions. We focus on stroke both because it is the leading cause of neurological disability worldwide and because we anticipate that advances in the reversal of stroke-related deficits will have ripple effects benefiting people with other neurological conditions including spinal cord injury, traumatic brain injury, ALS, and muscular dystrophy.

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Section: Stimulation Of the Brain To Enhance Motor Plasticity And Rec...mentioning

confidence: 99%

mentioning

confidence: 99%

An artificial nervous system to treat chronic stroke

Serruya

Rosenwasser

2021

Artificial Organs

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Deep brain stimulation for movement disorders after stroke: a systematic review of the literature

Paro

Michal

Ramanan

et al. 2022

Journal of Neurosurgery

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OBJECTIVE Stroke remains the leading cause of disability in the United States. Even as acute care for strokes advances, there are limited options for improving function once the patient reaches the subacute and chronic stages. Identification of new therapeutic approaches is critical. Deep brain stimulation (DBS) holds promise for these patients. A number of case reports and small case series have reported improvement in movement disorders after strokes in patients treated with DBS. In this systematic review, the authors have summarized the patient characteristics, anatomical targets, stimulation parameters, and outcomes of patients who have undergone DBS treatment for poststroke movement disorders. METHODS The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The PubMed, Scopus, and SpringerLink databases were searched for the keywords "DBS," "stroke," "movement," and "recovery" to identify patients treated with DBS for movement disorders after a stroke. The Joanna Briggs Institute Critical Appraisal checklists for case reports and case series were used to systematically analyze the quality of the included studies. Data collected from each study included patient demographic characteristics, stroke diagnosis, movement disorder, DBS target, stimulation parameters, complications, and outcomes. RESULTS The authors included 29 studies that described 53 patients who underwent placement of 82 total electrodes. Movement disorders included tremor (n = 18), dystonia (n = 18), hemiballism (n = 6), spastic hemiparesis (n = 1), chorea (n = 1), and mixed disorders (n = 9). The most common DBS targets were the globus pallidus internus (n = 32), ventral intermediate nucleus of thalamus (n = 25), and subthalamic area/subthalamic nucleus (n = 7). Monopolar stimulation was reported in 43 leads and bipolar stimulation in 13. High-frequency stimulation was used in 57 leads and low-frequency stimulation in 6. All patients but 1 had improvement in their movement disorders. Two complications were reported: speech impairment in 1 patient and hardware infection in another. The median (interquartile range) duration between stroke and DBS treatment was 6.5 (2.1–15.8) years. CONCLUSIONS This is the first systematic review of DBS for poststroke movement disorders. Overall, most studies to date have been case reports and small series reporting heterogeneous patients and surgical strategies. This review suggests that DBS for movement disorders after a stroke has the potential to be effective and safe for diverse patients, and DBS may be a feasible option to improve function even years after a stroke.

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Deep Brain Stimulation and Thalamotomy for the Treatment of Dystonia Acquired by Moyamoya Disease with Stroke

Cited by 2 publications

References 16 publications

An artificial nervous system to treat chronic stroke

An artificial nervous system to treat chronic stroke

Deep brain stimulation for movement disorders after stroke: a systematic review of the literature

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