Deep Brain Stimulation

Kern, Drew S.; Kumar, Rajeev

doi:10.1097/nrl.0b013e3181492c48

Cited by 76 publications

(39 citation statements)

References 163 publications

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“…Invasive and non-invasive forms of therapeutic treatments such as deep brain stimulation, glial cell-line derived neurotrophic factor (GDNF) releasing cell transplant, L-Dopa and exercise are used to alleviate the symptoms of Parkinson's disease (Lloyd et al, 1975;Alexi et al, 2000;Frank et al, 2007;Kern and Kumar, 2007). However, their effects are short-lived and possess side effects (Howells et al, 2005;Frank et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

2015

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Section: Introductionmentioning

confidence: 99%

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

2015

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“…Deep brain stimulation (DBS) is an established treatment for PD and the subthalamic nucleus (STN) is currently the target of choice. The efficacy of DBS on motor symptoms has been documented in several studies (17)(18)(19)(20)(21). Few studies have however focused on DBS and swallowing function, and no longitudinal study objectively monitoring swallowing function has been conducted.…”

Section: Introductionmentioning

confidence: 99%

Deep brain stimulation - effects on swallowing function in Parkinson's disease

et al. 2012

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ObjectiveIn patients with Parkinson's disease (PD), deep brain stimulation of the subthalamic nucleus (STN DBS) is well recognized in improving limb function, but the outcome on swallowing function has rarely been studied. The aim of this work was to evaluate the effect of STN DBS on pharyngeal swallowing function in PD patients using self-estimation and fiberoptic endoscopic evaluation of swallowing. MethodsEleven patients (aged 41-72, median 61 years) were evaluated preoperatively and at 6 and 12 months after STN DBS surgery. All patients were evaluated with self-estimation on a visual analogue scale and eight of them with a fiberoptic endoscopic examination with a predefined swallowing protocol including Rosenbek's Penetration-Aspiration Scale, Secretion Severity Scale, preswallow spillage, pharyngeal residue and pharyngeal clearance. ResultsThe self-assessments of swallowing function revealed a swallowing improvement with STN DBS stimulation whereas the data from the swallowing protocol did not show any significant effect of the STN DBS treatment itself. The prevalence of aspiration was not affected by the surgery. ConclusionsThe results show that swallowing function was neither improved nor negatively affected by STN DBS and the risk of aspiration did not increase. Self-estimation of swallowing function showed an improvement due to stimulation.

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“…Deep brain stimulation (DBS) is finding increased application in the therapy of numerous neurological and psychiatric diseases [1,2] . As new deep brain targets are being proposed and investigated, methods are required to evaluate and optimize these targets based on outcome [3,4] .…”

Section: Introductionmentioning

confidence: 99%

Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using a ‘Roving Window’ Interpolation Algorithm

Shenai

Walker²,

Guthrie³

et al. 2009

Stereotact Funct Neurosurg

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The delivery of stimulus by a deep brain stimulation (DBS) contact electrode at a particular location may lead to a quantifiable physiologic effect, both intraoperatively and postoperatively. Consequently, measured data values can be attributed to discrete scattered points in neuroanatomic space, allowing for interpolative techniques to generate a topographic map of spatial patterns. Ultimately, by relating the topographies of various intraoperative measurements to the postoperative counterparts and neuroanatomic atlases, outcome-guided adjustments to electrode position can be pursued intraoperatively. In this study, 52 Parkinson’s disease patients were tested with a postoperative trial of stimulation and thresholds were recorded for motor adverse effects. A ‘roving window’ interpolation algorithm was adapted to generate a topographic map of voltage threshold along selected axial, coronal and sagittal planes. By developing these relational topographies for a variety of intraoperative and postoperative effects, a multivariable approach towards DBS optimization emerges.

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Deep Brain Stimulation

Cited by 76 publications

References 163 publications

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

Early use of oleanolic acid provides protection against 6-hydroxydopamine induced dopamine neurodegeneration

Deep brain stimulation - effects on swallowing function in Parkinson's disease

Construction of Relational Topographies from the Quantitative Measurements of Functional Deep Brain Stimulation Using a ‘Roving Window’ Interpolation Algorithm

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