Deep Anterior Lamellar Keratoplasty and Penetrating Keratoplasty for Keratoconus: A Claims-Based Analysis

Abstract

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Prevalence and Associations of Keratoconus Among Children, Adults, and Elderly in the Population-Based Ural Eye Studies

“…1), so the finding of a relatively high keratoconus prevalence was not due to an uneven distribution of the parameter. The finding of a keratoconus of 6.45% in our study population is unusual as even in high-prevalence regions, such as Iran, individuals with an age of older than 50 years have been reported to have a keratoconus prevalence of ~3%–4% 9 . In addition, the keratoconus prevalence has not been found to increase in adults with an age of more than 30 years.…”

“…The finding of a keratoconus of 6.45% in our study population is unusual as even in high-prevalence regions, such as Iran, individuals with an age of older than 50 years have been reported to have a keratoconus prevalence of ~3%-4%. 9 In addition, the keratoconus prevalence has not been found to increase in adults with an age of more than 30 years. A factor that may have influenced the determined prevalence rate of keratoconus in this elderly study population might have been the relatively low participation rate of 42.7% (ie, 651 individuals with keratometric readings of both eyes out of 1526 primarily examined individuals).…”

“…We used in our study the keratoconus definition of a keratometric reading of ≥48 D, whereas other studies applied different parameters based on corneal imaging 26 . Second, by the same token, by using only the keratometric reading for the definition of keratoconus one might have missed subclinical and mild forms of keratoconus, potentially explaining that the prevalence values of keratoconus in the UCES and UEMS tended to be at the lower end of the spectrum of keratoconus prevalence rates as reported in previous studies on other study populations 9–16 . Retrospectively, the built-in indices of the Scheimflug camera might have been alternative and more sensitive and specific diagnostic parameters for the definition and detection of keratoconus in our study.…”

“…Keratoconus is typically first noticed during puberty and tends to progress until the third decade of life. In advanced cases, it can result in significant vision impairment, sometimes even necessitating corneal transplantation 7–9 …”

“…In advanced cases, it can result in significant vision impairment, sometimes even necessitating corneal transplantation. [7][8][9] In the last 4 decades, multiple population studies have reported varying prevalence rates of keratoconus, with different disease definitions applied. The prevalence has ranged widely, from as low as 0.0003% (0.3/100,000) in Russia to as high as 3.6% (96/2667) in rural areas of Southwest and North Iran.…”