Deep Active Contour-Based Capsule Network for Medical Image Segmentation

Soora, Narasimha Reddy; Mohammed, Ehsan Ur Rahman; Mohammed, Sharfuddin Waseem; Kumar, Nalini

doi:10.1080/03772063.2022.2098184

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…They could be more computationally efficient for multicell tracking. As examples, parametric models, including an active contour-based "snakes" model in two dimensions [20], and a dynamic mesh or a deformable model in three dimensions [21], may be used. Implicit methods such as the advanced level-set-based multicell segmentation and tracking algorithm and the Chan-Vese Model, may also be used; these methods naturally manage splits, and they merge the new appearances of the cells [22,23].…”

Section: Introduction 1backgroundmentioning

confidence: 99%

A Weakly Supervised Learning Method for Cell Detection and Tracking Using Incomplete Initial Annotations

Wu,

Niyogisubizo,

Zhao

et al. 2023

IJMS

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The automatic detection of cells in microscopy image sequences is a significant task in biomedical research. However, routine microscopy images with cells, which are taken during the process whereby constant division and differentiation occur, are notoriously difficult to detect due to changes in their appearance and number. Recently, convolutional neural network (CNN)-based methods have made significant progress in cell detection and tracking. However, these approaches require many manually annotated data for fully supervised training, which is time-consuming and often requires professional researchers. To alleviate such tiresome and labor-intensive costs, we propose a novel weakly supervised learning cell detection and tracking framework that trains the deep neural network using incomplete initial labels. Our approach uses incomplete cell markers obtained from fluorescent images for initial training on the Induced Pluripotent Stem (iPS) cell dataset, which is rarely studied for cell detection and tracking. During training, the incomplete initial labels were updated iteratively by combining detection and tracking results to obtain a model with better robustness. Our method was evaluated using two fields of the iPS cell dataset, along with the cell detection accuracy (DET) evaluation metric from the Cell Tracking Challenge (CTC) initiative, and it achieved 0.862 and 0.924 DET, respectively. The transferability of the developed model was tested using the public dataset FluoN2DH-GOWT1, which was taken from CTC; this contains two datasets with reference annotations. We randomly removed parts of the annotations in each labeled data to simulate the initial annotations on the public dataset. After training the model on the two datasets, with labels that comprise 10% cell markers, the DET improved from 0.130 to 0.903 and 0.116 to 0.877. When trained with labels that comprise 60% cell markers, the performance was better than the model trained using the supervised learning method. This outcome indicates that the model’s performance improved as the quality of the labels used for training increased.

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Section: Introduction 1backgroundmentioning

confidence: 99%

A Weakly Supervised Learning Method for Cell Detection and Tracking Using Incomplete Initial Annotations

Wu,

Niyogisubizo,

Zhao

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Nevertheless, it requires an initial contour line to start the iteration, meaning that it is sensitive to the initial profile setting. Then, Soora et al [18] modified the active contour model to be differentiable and combined it with a deep neural network. Meanwhile, a new loss function incorporating external forces and regional information was used, which enhanced the segmentation robustness.…”

Section: Introductionmentioning

confidence: 99%