Deduction and exploration of the evolution and function of vertebrate GFPT family

Wei, Siang; Xu, Ran; Ji, Yuyao; Ding, Zhiwen; Zou, Yunzeng

doi:10.1007/s13258-021-01188-8

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…6g ). The ubiquitination of GFPT2 is essential for its activity 24 . We next examined the role of MAVS on GFPT2 ubiquitination.…”

Section: Resultsmentioning

confidence: 99%

MAVS integrates glucose metabolism and RIG-I-like receptor signaling

He,

Huang,

Nie

et al. 2023

Nat Commun

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MAVS is an adapter protein involved in RIG-I-like receptor (RLR) signaling in mitochondria, peroxisomes, and mitochondria-associated ER membranes (MAMs). However, the role of MAVS in glucose metabolism and RLR signaling cross-regulation and how these signaling pathways are coordinated among these organelles have not been defined. This study reports that RLR action drives a switch from glycolysis to the pentose phosphate pathway (PPP) and the hexosamine biosynthesis pathway (HBP) through MAVS. We show that peroxisomal MAVS is responsible for glucose flux shift into PPP and type III interferon (IFN) expression, whereas MAMs-located MAVS is responsible for glucose flux shift into HBP and type I IFN expression. Mechanistically, peroxisomal MAVS interacts with G6PD and the MAVS signalosome forms at peroxisomes by recruiting TNF receptor-associated factor 6 (TRAF6) and interferon regulatory factor 1 (IRF1). By contrast, MAMs-located MAVS interact with glutamine-fructose-6-phosphate transaminase, and the MAVS signalosome forms at MAMs by recruiting TRAF6 and TRAF2. Our findings suggest that MAVS mediates the interaction of RLR signaling and glucose metabolism.

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“…6g ). The ubiquitination of GFPT2 is essential for its activity 24 . We next examined the role of MAVS on GFPT2 ubiquitination.…”

Section: Resultsmentioning

confidence: 99%

MAVS integrates glucose metabolism and RIG-I-like receptor signaling

He,

Huang,

Nie

et al. 2023

Nat Commun

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From metabolism to disease: the biological roles of glutamine:fructose-6-phosphate amidotransferase (GFAT)

Oliveira,

Lucena,

Rodrigues

et al. 2023

Pure and Applied Chemistry

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Glutamine:fructose-6-phosphate amidotransferase (GFAT) is the rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP), an important route for de novo synthesis of amino sugars, which are key components of prokaryotic cell walls, chitin, and complex eukaryotic glycoconjugates. GFAT also plays a major role in several pathological processes, including cancer and diabetes. It has been 60 years since GFAT was first characterized. During this time, the knowledge about the enzyme’s mechanisms and biological relevance has increased considerably. We take the anniversary of GFAT’s discovery as an opportunity to discuss the role of GFAT in both health and disease and explore its biotechnological potential as a target for antimicrobial and anticancer chemotherapy.

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Deduction and exploration of the evolution and function of vertebrate GFPT family

Cited by 2 publications

References 45 publications

MAVS integrates glucose metabolism and RIG-I-like receptor signaling

MAVS integrates glucose metabolism and RIG-I-like receptor signaling

From metabolism to disease: the biological roles of glutamine:fructose-6-phosphate amidotransferase (GFAT)

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