Dedifferentiation of a growth-hormone secreting pituitary adenoma to a non-secreting carcinoma

Flitsch, Jörg; Lüdecke, D.; Saeger, Wolfgang; Westphal, Milton

doi:10.1055/s-2005-863016

Cited by 2 publications

(1 citation statement)

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“…In our series of 7602 pituitary lesions since 1970, 12 carcinomas (Table 8) were collected. Seven could be classified as ACTH cell carcinomas, three as PRL cell carcinomas, and two as GH cell carcinomas (90,91,95). The prognosis of pituitary carcinomas is generally poor, although patients with long-term survival have been described (96).…”

Section: Pituitary Carcinomasmentioning

confidence: 99%

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

524

346

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In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be reported. The data supplement former collections of the years 1970-1995 with 3480 surgically removed tumors or lesions of the pituitary region. The cases were studied using histology, immunostainings and in some cases also molecular pathology or electron microscopy. The adenomas were classified according to the current World Health Organization classification in the version of 2004. From 1996 on 3489 adenomas (84.6%), 5 pituitary carcinomas (0.12%), 133 craniopharyngiomas (3.2%), 39 meningiomas (0.94%), 25 metastases (0.6%), 22 chordomas (0.5%), 115 cystic non-neoplastic lesions (2.8%), and 46 inflammatory lesions (1.1%, 248 other lesions or normal tissue (6.0%)) were collected by us. The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).

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Section: Pituitary Carcinomasmentioning

confidence: 99%