Dedifferentiated liposarcoma of the oral floor: A case study and literature review of 50�cases of head and neck neoplasm

Abstract

Dedifferentiated liposarcoma (DDLS) has a relatively poor prognosis, however this neoplasm rarely occurs in the head and neck. To date, no definite protocol has been established for the diagnosis and treatment of head and neck DDLS. The present study reports the case of a 69-year-old male patient with DDLS of the oral floor. To the best of our knowledge, this is the first documented case of oral floor DDLS. In addition, this is the first reported case with the development of a second primary malignancy following the treatment of head and neck DDLS. A literature review of 50 cases of head and neck DDLS revealed that preoperative biopsy is not reliable for the diagnosis of these tumors and an accurate pathological diagnosis with total resection is preferred.

Hypopharyngeal Dedifferentiated Liposarcoma in the MDM2 Era: A Case Report and Short Review

“…In all sites including outside the head and neck, liposarcoma is the most common tumor among sarcomas of the soft tissue and is categorized into four subgroups: atypical lipomatous tumor/well-differentiated liposarcoma (WDLS) [5], dedifferentiated liposarcoma (DDLS), myxoid liposarcoma, and pleomorphic liposarcoma [4]. DDLS is an aggressive malignancy; hence, its recurrence and metastasis rates are higher than those of other types of liposarcoma [3,6,7].…”

Liposarcoma of oral cavity: Systematic review of cases reported to date and analysis of prognostic factors

“…Liposarcomas (LPSs) are the most common soft tissue sarcomas in adults and represent 16% to 20% of all malignant soft tissue neoplasms. [1][2][3] LPSs were first described by Virchows in 1857 as malignant neoplasms of the adipose tissue. [3][4][5] The lesion can affect all body regions, but it is mostly observed in sites below the waist, such as in the lower limb and retroperitoneum.…”

“…[3][4][5] The lesion can affect all body regions, but it is mostly observed in sites below the waist, such as in the lower limb and retroperitoneum. 1,2,6 LPSs are rare in the head and neck region and represents 5% to 9% of the cases of sarcomas in this region. 3,4,6 In the oral cavity, the lesion is even rarer, representing just 0.3% of all sarcomas.…”

“…LPSs were first described by Virchows in 1857 as malignant neoplasms of the adipose tissue 3‐5 . The lesion can affect all body regions, but it is mostly observed in sites below the waist, such as in the lower limb and retroperitoneum 1,2,6 . LPSs are rare in the head and neck region and represents 5% to 9% of the cases of sarcomas in this region 3,4,6 .…”

“…For this reason, there is limited information in the literature regarding factors influencing survival, recurrence, and distant metastasis. The epidemiological study of such rare lesions is of great importance because it could improve diagnostic accuracy and allow surgeons to make informed decisions and refine the treatment plan to optimize the clinical outcome 1,2,4 . The aim of the present study was to integrate the available data published in the literature on LPSs of the oral cavity to allow a comprehensive, up‐to‐date analysis of its clinical features, treatment modalities, survival and recurrence influencing factors.…”