Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy

Saifuddin, Asif; Mann, Bhupinder; Mahroof, S.; Pringle, J.; Briggs, Timothy; Cannon, Stephen R.

doi:10.1016/j.crad.2003.08.009

Cited by 41 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Morphology and immunophenot conWrmed that the most frequent high-grade tumor in DDCS is the MFH, conWrmed by our analysis as well (18 MFH in 25 DCHSA) (Wick and Siegal 1987;Kinkor and Lunácková 2003;Rinaggio et al 2004;Saifuddin et al 2004, Staals et al 2006). In addition to the above, OSa, FSa, RMSa and angiosarcoma are also reported in the literature as the possible DDCS components (Wick and Pring and Weber 2001;Casorzo andChiecchio 2003, Röpke et al 2003;Dickey and Rose 2004;Rinaggio et al 2004;Bruns and Fiedler 2005).…”

Section: Discussionsupporting

confidence: 84%

Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases

Sopta¹,

Đorđević

Tulic³

et al. 2007

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 84%

Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases

Sopta¹,

Đorđević

Tulic³

et al. 2007

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

“…In this regard, a possible approach could be to use MRI to select specific areas of the tumor to be sampled. It has been shown that reduced signal intensity on T2-weighted MRI may represent foci of dedifferentiation and should be the preferred site of biopsy [23]. All of our biopsies were done by experienced musculoskeletal radiologists who had MRI findings in most cases and attempted to target the areas that looked by imaging to be the area of highest grade.…”

Section: Discussionmentioning

confidence: 99%

“…There is considerable interobserver variability among pathologists when dealing with cartilaginous tumors [8,22,23]; therefore, the role of preoperative biopsy has been controversial. Clinical manifestations and radiological features are used, alone or correlated with histology, to make therapeutic decisions [2,5,7,11,14,22,27].…”

Section: Introductionmentioning

confidence: 99%

Is Needle Biopsy Clinically Useful in Preoperative Grading of Central Chondrosarcoma of the Pelvis and Long Bones?

Roitman

Farfalli

Ayerza

et al. 2017

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background Central chondrosarcoma of bone is graded on a scale of 1 to 3 according to histological criteria. Clinically, these tumors can be divided into low-grade (Grade 1) and high-grade (Grade 2, Grade 3, and dedifferentiated) chondrosarcomas. Although en bloc resection has been the most widely used treatment, it has become generally accepted that in selected patients with low-grade chondrosarcomas of long bones, curettage is safe and effective. This approach requires an accurate preoperative estimation of grade to avoid under-or overtreatment, but prior reports have indicated that both imaging and biopsy do not always give an accurate prediction of grade. Questions/purposes (1) What is the concordance of image-guided needle preoperative biopsy and postoperative grading in central (intramedullary) chondrosarcomas of long bones, and how does this compare with the concordance of image-guided needle preoperative biopsy and postoperative grading in central pelvic chondrosarcomas? (2) What is the concordance of preoperative image-guided needle biopsy and postoperative findings in differentiating low-grade from high-grade central chondrosarcomas of long bones, and how does this compare with the concordance in central pelvic chondrosarcomas? Methods Between 1997 and 2014, in our institution, we treated 126 patients for central chondrosarcomas located in long bones and the pelvis. Of these 126 cases, 41 were located in the pelvis and the remaining 85 cases were located in long bones. This study considers 39 (95%) and 40 (47%) of them, respectively. We included all cases in which histological information was complete regarding preoperative and postoperative tumor grading. We excluded all cases with incomplete data sets or nondiagnostic preoperative biopsies. To evaluate the needle biopsy accuracy, we compared the histological tumor grade, obtained from the preoperative biopsy, with the final histological grade obtained from the postoperative surgical specimen. The weighted and nonweighted kappa statistics were used to evaluate the agreement. Results Concordance between the preoperative biopsy and the final pathological analysis in terms of histological grade was much higher in long-bone chondrosarcoma than in pelvic chondrosarcoma (83% [33 of 40] versus 36% [14 of 39]; odds ratio, 8, 48). Likewise, the weighted kappa coefficients were higher in long-bone chondrosarcoma than One of the authors certifies that he (LAA-T) or a member of his immediate family, has or may receive payments or benefits, during the study period, an amount of USD 10,000 to USD 100,000 from Stryker Americas (Miramar, FL, USA). All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research 1 editors and board members are on file with the publication and can be viewed on request. Each author certifies that his institution has approved the reporting of this study and that all investigations were conducted in conformity with ethical principles of research. This work was performed at the Italian Hospital of Bue...

show abstract

“…16), which enhances uniformly with contrast medium, the features not being typical for low-grade cartilage [66,67]. T2W MRI can be used to target areas of suspected dedifferentiation for image guided needle biopsy [68].…”

Section: Dedifferentiation Of Benign and Low-grade Malignant Tumoursmentioning

confidence: 99%

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

et al. 2007

View full text Add to dashboard Cite

MRI has an established role in the local staging of primary bone tumours. However, as the majority of tumours have non-specific appearances on MRI, the diagnosis is usually established on the basis of clinical history, plain film findings and biopsy. This article reviews the value of MRI in the further characterisation of appendicular bone tumours and tumour-like lesions, with particular reference to peri-lesional oedema, fluid-fluid levels, flow voids, fat signal, cartilage signal and dedifferentiation. These features are a useful adjunct for distinguishing between benign and malignant disease, pointing towards a more specific diagnosis, and guiding biopsy.

show abstract

Dedifferentiated chondrosarcoma: use of MRI to guide needle biopsy

Cited by 41 publications

References 19 publications

Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases

Dedifferentiated chondrosarcoma: our clinico-pathological experience and dilemmas in 25 cases

Is Needle Biopsy Clinically Useful in Preoperative Grading of Central Chondrosarcoma of the Pelvis and Long Bones?

The role of MR imaging in the diagnostic characterisation of appendicular bone tumours and tumour-like conditions

Contact Info

Product

Resources

About