Dedifferentiated Chondrosarcoma: Diagnostic Controversies and Emerging Therapeutic Targets

El Beaino, Marc; Hoda, Syed T.; Eldeib, Ahmed J.; Masrouha, Karim

doi:10.1007/s11912-023-01441-1

Cited by 3 publications

(2 citation statements)

References 93 publications

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“…By definition, peripheral CSs are always associated with an extraosseous component; in dedifferentiated CS, the tumor presents as a low-grade, cartilaginous tumor juxtaposed to a generally high-grade, mesenchymal, non-cartilaginous component. In dedifferentiated CS, the high-grade non-cartilaginous component is thought to be more responsible for the diminished survival [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?

Laitinen,

Parry,

Morris

et al. 2024

Cancers

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Background: Chondrosarcoma (CS) is the second most common surgically treated primary malignancy of the bone. The current study explored the effect of the margin and extraosseous tumor component in CS in the femur on local recurrence (LR), LR-free survival (LRFS), and disease-specific survival (DSS). Methods: Among 202 patients, 115 were in the proximal extremity of the femur, 4 in the corpus of the femur, and 83 in the distal extremity of femur; 105 patients had an extraosseous tumor component. Results: In the Kaplan–Meier analysis, factors significant for decreased LRFS were the extraosseous tumor component (p < 0.001), extraosseous tumor component arising from the superior aspect (p < 0.001), histological grade (p = 0.031), and narrow surgical margin < 3 mm (p < 0.001). Factors significantly affecting DSS were the histological grade (p < 0.001), extraosseous component (p < 0.001), LR (p < 0.001), metastases (p < 0.001), and surgical margin (p < 0.001). Conclusions: In CS of the femur, the presence of an extraosseous tumor component has a predictive role in LRFS, and extraosseous tumor component arising from the superior aspect was significant for decreased LRFS. Wide margins were more commonly achieved when the tumor had only an intraosseous component, and the rate of LR was significantly higher in cases with an extraosseous tumor component. When the extraosseous component arose from the superior aspect of the femur, LR occurred more frequently despite achieving adequate margins.

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Section: Discussionmentioning

confidence: 99%

Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?

Laitinen,

Parry,

Morris

et al. 2024

Cancers

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show abstract

“…Dedifferentiation can occur either initially or during a local recurrence of a previously treated low-grade chondrosarcoma. Pain is the most common presenting symptom in the majority of cases [5].…”

Section: Discussionmentioning

confidence: 99%

Surgical Management and Reconstruction of Dedifferentiated Chondrosarcoma in the Proximal Femur: A Case Report

Lahrach,

Jaafar,

Al Idrissi

2024

Cureus

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Comparisons of clinical characteristics, treatments, and outcomes among different pathological subtypes of chondrosarcoma in the spine

Sun,

Wu,

Jiao

et al. 2024

J Neurooncol

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Dedifferentiated Chondrosarcoma: Diagnostic Controversies and Emerging Therapeutic Targets

Cited by 3 publications

References 93 publications

Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?

Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?

Surgical Management and Reconstruction of Dedifferentiated Chondrosarcoma in the Proximal Femur: A Case Report

Comparisons of clinical characteristics, treatments, and outcomes among different pathological subtypes of chondrosarcoma in the spine

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