Dedication

Benzon, Honorio T.; Raja, Srinivasa N.; Liu, Spencer S.; Fishman, Scott M.; Cohen, Steven P.; Hurley, Robert W.; Malik, Khalid Mahmood; Peng, Philip

doi:10.1016/b978-0-323-40196-8.03001-1

Cited by 16 publications

(29 citation statements)

References 0 publications

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“…The release of substance P and gross mast cell activation results in neurogenic inflammation [11]. Common examples of nociceptive pain include postoperative pain and cancer pain [12]. Neuropathic pain, on the other hand, is pain derived from a lesion or dysfunction within the nervous system itself (e.g., peripheral neuropathy, herpes zoster), and it rarely has nociceptive stimulation [13].…”

Section: Neurobiology Of Painmentioning

confidence: 99%

“…Peripheral sensitization occurs from increased sensitivity at the level of the peripheral nerve due to a continuous nociceptive response [12]. This reduces the nerve activation threshold and makes them more reactive.…”

Section: Neurobiology Of Painmentioning

confidence: 99%

“…This reduces the nerve activation threshold and makes them more reactive. Central sensitization, characterized by a CNS disturbance in pain processing, is thought to be an important in the pathology of many chronic pain syndromes (fibromyalgia, chronic low back pain, temporomandibular disorder and irritable bowel syndrome) [12]. In its purest form, there is no ongoing nociceptive stimulation from the periphery; however, there may be a combination of peripheral nociceptive signals and spontaneous signals from damaged peripheral nerves, resulting in neuronal remodeling along the pathway from the periphery to the pain processing center in the brain [12].…”

Section: Neurobiology Of Painmentioning

confidence: 99%

“…While traditionally prescribed for neuropathic pain, these have been successfully employed in nonspecific pain conditions as well as those with primary musculoskeletal dysfunction (i.e., fibromyalgia) [12]. …”

Section: Membrane Stabilizersmentioning

confidence: 99%

“…Anxiolytics and typical/atypical neuroleptics have also been used with some benefit in the treatment of pain disorders. While some anxiolytics provide an analgesic effect through the increase of inhibitory GABA and subsequent reduction in motor neuron excitation, cautious use recommended due to risk of dependency and abuse [12]. There are no published studies specific to women with CPP.…”

Section: Othermentioning

confidence: 99%

See 4 more Smart Citations

New Developments in the Pharmacotherapy of Neuropathic Chronic Pelvic Pain

Carey

As‐Sanie

2016

Future Science OA

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Advancements in further understanding the pathophysiology of chronic pelvic pain syndromes continue to direct therapy. The mechanisms of chronic pelvic pain are often multifactorial and therefore require a multidisciplinary approach. The final treatment plan is often an accumulation of organ-specific treatment and chronic pain medications directed to the CNS and PNS. This article is a review of commonly used medications for chronic pelvic neuropathic pain disorders as well as an introduction to recent innovative developments in pain medicine.

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Section: Neurobiology Of Painmentioning

confidence: 99%

Section: Neurobiology Of Painmentioning

confidence: 99%

Section: Neurobiology Of Painmentioning

confidence: 99%

Section: Membrane Stabilizersmentioning

confidence: 99%

Section: Othermentioning

confidence: 99%

See 3 more Smart Citations

New Developments in the Pharmacotherapy of Neuropathic Chronic Pelvic Pain

Carey

As‐Sanie

2016

Future Science OA

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Endometriosis Pain Management: a Review

Carlyle

Khader

Lam

et al. 2020

Curr Pain Headache Rep

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Purpose of ReviewThe purpose of this review is to summarize the up-to-date pain management options and recommendations for the challenging disease, endometriosis. Recent Findings The mainstays of endometriosis advances of both surgical and medical management continue to evolve. Experimental pharmaceuticals include Gestirone, and aromatase inhibitors have shown promise but are still under scrutiny. Surgical techniques include laparoscopic uterosacral nerve ablation/resection and presacral neurectomy. Summary No studies have directly compared medical versus surgical management, and as such, no one treatment modality can be recommend as superior to the other. Patients may initially be given a medical diagnosis and treated with nonsteroidal antiinflammatory drugs, neurolepitcs, OCP, GNRH agonists/antagonists, and Danazol. Assessing the success of these regimens has proved difficult. Surgical management relies on various methods including excision/ablation of the lesions, nerve ablation, neurectomy, hysterectomy, and oophorectomy. KeywordsEndometriosis . Endometriosis pain management . Surgical management endometriosis . Medical management endometriosis . Endometriosis adjuvants . Endometriosis experimental treatments This article is part of the Topical Collection on Other Pain * Daniel Carlyle

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Design, Prototyping, and Characterization of a Micro-Force Sensor Intended for Tissue Assessment in Confined Spaces

Kumat,

Shiakolas

2024

IEEE Sensors J.

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The quantitative characterization of soft tissue viscoelastic properties can aid in disease prognosis and diagnosis. Existing technologies present challenges to measuring localized in-vivo tissue relaxation data while meeting load and geometric constraints. This research presents the design, prototype and characterization of a micro-force sensor that could enable better access to confined spaces of the human body. The novel design of the uni-axial micro-force sensor has an external diameter of less than or equal to 3.5 mm and 1 N load capacity for transurethral palpation of the bladder interior wall. The conceptual design of the micro-force sensor and a finite element based discrete optimization procedure to determine the optimum values of the identified design parameters of bend radius, bend angle, and thickness while meeting defined operational and geometric constraints are presented. These optimum values guided the prototyping of an aluminum sensing element with 2.18 mm bend radius, 104.9 • bend angle, and 0.3 mm thickness. A miniature metal foil strain gauge was attached at defined location on the sensing element for measurement purposes. An experimental testbed was developed, calibrated and used for characterization experiments. The performance matrix of the prototyped micro-force sensor was experimentally evaluated. The sensitivity, resolution, accuracy, precision, and repeatability band of the sensor were evaluated to be 859.73 µ /N, 2.6 mN, 28.6 mN, 87.22%, and ± 2.87% respectively with a hysteresis of 118 mN. These experimental results provide confidence to further employ the sensor for in-vivo experiments towards the identification of viscoelastic properties of soft tissue.

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Dedication

Cited by 16 publications

References 0 publications

New Developments in the Pharmacotherapy of Neuropathic Chronic Pelvic Pain

New Developments in the Pharmacotherapy of Neuropathic Chronic Pelvic Pain

Endometriosis Pain Management: a Review

Design, Prototyping, and Characterization of a Micro-Force Sensor Intended for Tissue Assessment in Confined Spaces

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