Dedicated PET scanners for breast imaging

Freifelder, R.; Karp, Joel S.

doi:10.1088/0031-9155/42/12/012

Cited by 95 publications

(58 citation statements)

References 18 publications

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“…To overcome such limitations, dedicated PET scanners for breast imaging have been developed, and initial reports have described the potential clinical value of the higher spatial resolution and sensitivity that is achievable with these devices (8)(9)(10). Bowen et al (11) classified dedicated PET scanners for breast imaging into 2 groups.…”

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confidence: 99%

Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation

et al. 2012

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The purpose of this study was to investigate the diagnostic performance of 2 newly developed dedicated breast PET scanners in patients with known or suspected breast cancer. Methods: Two types of scanner were evaluated, an O-shaped scanner and a C-shaped scanner. The O scanner was designed for imaging patients who were prone, and the C scanner was designed for those patients positioned leaning forward. Sixty-nine women with known or suspected breast carcinoma (80 lesions: 72 invasive carcinomas, 4 noninvasive carcinomas [ductal carcinoma in situ, or DCIS], 1 case of adenomatous ductal hyperplasia, and 3 benign lesions) were enrolled in this study. All patients underwent a conventional whole-body PET/CT scan, followed by breast scanning using both dedicated devices. The diagnostic performance of each scanner was assessed. Results: The maximal diameter of invasive tumors ranged from 4 to 112 mm, with an average of 26 mm. With the O scanner, 62 of 76 malignant lesions (including 3 DCIS) were detected, 5 lesions were not detected, and the remaining 9 lesions were outside the field of view. With the C scanner, 63 of 76 malignant lesions (including 2 DCIS) were detected, 7 lesions were not detected, and the remaining 6 lesions were outside the field of view. The lesion-based sensitivities of the O and C scanners were 82% (62/76) and 83% (63/76), respectively; sensitivities excluding lesions outside the field of view were 93% (62/67) and 90% (63/70), respectively. The sensitivity of conventional PET/CT was 92% (70/76). All lesions outside the field of view were close to the chest wall. The breast-based specificities of the O, C, and conventional scanners were 98% (48/49), 98% (56/57), and 100% (70/70), respectively. Conclusion: Our preliminary study indicates that both dedicated breast PET scanners are clinically feasible and yield reasonably high sensitivity. More detailed information was obtained with these scanners than with the conventional scanner.

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confidence: 99%

Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation

et al. 2012

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“…Dedicated PET, commonly referred to as positron emission mammography (PEM), has been developed for imaging breast [1], [2], [3], [4]. Comparing to whole body PET scanners, PEM scanners are built with much less number of detector modules and have higher sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Lesion detection and quantitation of positron emission mammography

Huesman

2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)

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Abstract-A Positron Emission Mammography (PEM) scanner dedicated to breast imaging is being developed at our laboratory. We have developed a list mode likelihood reconstruction algorithm for this scanner. Here we theoretically study the lesion detection and quantitation. The lesion detectability is studied theoretically using computer observers. We found that for the zero-order quadratic prior, the region of interest observer can achieve the performance of the prewhitening observer with a properly selected smoothing parameter. We also study the lesion quantitation using the test statistic of the region of interest observer. The theoretical expressions for the bias, variance, and ensemble mean squared error of the quantitation are derived. Computer simulations show that the theoretical predictions are in good agreement with the Monte Carlo results for both lesion detection and quantitation.

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“…Dedicated PET scanners, commonly referred to as positron emission mammography (PEM) cameras, are being developed to improve the cost effectiveness for detecting breast cancers [1][2][3][4][5]. These PEM scanners have special geometries that are different from the conventional circular design of whole body PET scanners.…”

Section: Introductionmentioning

confidence: 99%

“…These PEM scanners have special geometries that are different from the conventional circular design of whole body PET scanners. Compared to whole body PET, PEM has much greater sensitivity for detecting breast cancers [3].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of rectangular and dual-planar positron emission mammography scanners

Kuo

Huesman

et al.

2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)

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Abstract-Breast imaging using dedicated positron emission tomography (PEM) has gained much interest in the medical imaging field. In this paper, we compare the performance between a rectangular geometry and a parallel dual-planar geometry. Both geometries are studied with DOI detectors (detectors capable of measuring the depth of interaction) and non-DOI detectors. We compare the Fisher information matrix, lesion detection, and quantitation of the four systems. The lesion detectability is measured by the signal-to-noise ratio (SNR) of a prewhitening numerical observer for detecting a known hot spot on a uniform background. Results show that the rectangular system with DOI has the highest SNR for the detection task and the lowest bias at any given noise level for the quantitation task. They also show that for small simulated lesions the parallel dual-planar system with DOI detectors outperforms the rectangular system with non-DOI detectors, while the rectangular system with non-DOI detectors can outperform the parallel dual-planar system with DOI detectors for large simulated lesions.

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Dedicated PET scanners for breast imaging

Cited by 95 publications

References 18 publications

Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation

Clinical Performance of 2 Dedicated PET Scanners for Breast Imaging: Initial Evaluation

Lesion detection and quantitation of positron emission mammography

Comparison of rectangular and dual-planar positron emission mammography scanners

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