Dedicated 70 MHz RF systems for hyperthermia of challenging tumor locations

Crezee, J.; Zweije, Remko; Sijbrands, Jan; Kok, H. Petra

doi:10.1017/s1759078720000318

Cited by 5 publications

(3 citation statements)

References 43 publications

(55 reference statements)

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“…However, this delivery approach requires heating of the target region as a trigger for drug release. Advances in heating techniques, thermometry, and treatment planning have significantly expanded the types, volumes, and locations of tumors that are amenable to mild hyperthermic heating [47][48][49]. Thus, expanding the clinical scenarios in which thermosensitive liposomes can be explored.…”

Section: Discussionmentioning

confidence: 99%

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

Regenold

Wang

Kaneko

et al. 2022

Preprint

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Chemotherapy plays an important role in debulking tumors in advance of surgery and/or radiotherapy, tackling residual disease, and treating metastatic disease. In recent years many promising advanced drug delivery strategies have emerged that offer more targeted delivery approaches to chemotherapy treatment. For example, thermosensitive liposome mediated drug delivery in combination with localized mild hyperthermia can increase local drug concentrations resulting in a reduction in systemic toxicity and an improvement in local disease control. However, the majority of solid tumor associated deaths are due to metastatic spread. A therapeutic approach focused on a localized target area harbors the risk of overlooking and undertreating potential metastatic spread. Previous studies reported systemic, albeit limited, anti-tumor effects following treatment with thermosensitive liposomal chemotherapy and localized mild hyperthermia. This work explores the systemic treatment capabilities of a thermosensitive liposome formulation of the vinca alkaloid vinorelbine in combination with mild hyperthermia in an immunocompetent murine model of rhabdomyosarcoma. This treatment approach was found to be highly effective at heated, primary tumor sites. However, it demonstrated limited anti-tumor effects in secondary, distant tumors. As a result, the addition of immune checkpoint inhibition therapy was pursued to further enhance the systemic anti-tumor effect of this treatment approach. Once combined with immune checkpoint inhibition therapy, a significant improvement in systemic treatment capability was achieved. We believe this is one of the first studies to demonstrate that a triple combination of thermosensitive liposomes, localized mild hyperthermia, and immune checkpoint inhibition therapy can enhance the systemic treatment capabilities of thermosensitive liposomes.

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Section: Discussionmentioning

confidence: 99%

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

Regenold

Wang

Kaneko

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…However, this delivery approach requires heating of the target region as a trigger for drug release. Advances in heating techniques, thermometry, and treatment planning have signi cantly expanded the types, volumes, and locations of tumors that are amenable to mild hyperthermic heating [47][48][49]. Thus, expanding the clinical scenarios in which thermosensitive liposomes can be explored.…”

Section: Discussionmentioning

confidence: 99%

Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes

Regenold

Wang

Kaneko

et al. 2022

Drug Deliv. and Transl. Res.

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Chemotherapy plays an important role in debulking tumors in advance of surgery and/or radiotherapy, tackling residual disease, and treating metastatic disease. In recent years many promising advanced drug delivery strategies have emerged that offer more targeted delivery approaches to chemotherapy treatment. For example, thermosensitive liposome mediated drug delivery in combination with localized mild hyperthermia can increase local drug concentrations resulting in a reduction in systemic toxicity and an improvement in local disease control. However, the majority of solid tumor associated deaths are due to metastatic spread. A therapeutic approach focused on a localized target area harbors the risk of overlooking and undertreating potential metastatic spread. Previous studies reported systemic, albeit limited, anti-tumor effects following treatment with thermosensitive liposomal chemotherapy and localized mild hyperthermia. This work explores the systemic treatment capabilities of a thermosensitive liposome formulation of the vinca alkaloid vinorelbine in combination with mild hyperthermia in an immunocompetent murine model of rhabdomyosarcoma. This treatment approach was found to be highly effective at heated, primary tumor sites. However, it demonstrated limited anti-tumor effects in secondary, distant tumors. As a result, the addition of immune checkpoint inhibition therapy was pursued to further enhance the systemic anti-tumor effect of this treatment approach. Once combined with immune checkpoint inhibition therapy, a signi cant improvement in systemic treatment capability was achieved. We believe this is one of the rst studies to demonstrate that a triple combination of thermosensitive liposomes, localized mild hyperthermia, and immune checkpoint inhibition therapy can enhance the systemic treatment capabilities of thermosensitive liposomes.

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“…4,5 Furthermore, in the last years, adapting of near field beam steering principle to near field patterns of array antennas, the focusing proposals in free space are available in the papers. [6][7][8][9] In an article published in 2020, 10 the systems that enable the destruction of tumors in the leg, breast and thorax tissues by heating were introduced and the application results were conveyed. Although it was seen that the tumor tissues died in the applications, it was shared that the system also damaged the surrounding healthy tissues.…”

Section: Introductionmentioning

confidence: 99%

A novel near field radiation shaping technique by using data driven surrogate based optimization for nondestructive hyperthermia

Ünal

Mahoutı

Türk

2022

Int J Numerical Modelling

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Herein, a novel and computationally efficient near field shaping technique for nondestructive hyperthermia applications is presented. The aim of nondestructive hyperthermia studies is to treat cancer cells in the body without damaging the healthy cells using the focused near‐field characteristic of the antenna array. However, optimal near field shaping requires an optimization process for having accurately focus the energy into the desired coordinates, which is, a computational expensive and inefficient task due to the nature of full‐wave electromagnetic (EM) analysis. To enable computationally efficient, and accurate near field shape optimization, a surrogate model is required. To achieve this, the near field radiation of the designed horn antenna array in free space is obtained by using a fast and reliable technique, analytical regularization method (ARM). After that, by using Artificial Neural Network based regression algorithm, a data driven surrogate model is created using the data samples generated by ARM. By this means, near field shaping optimization for focusing the energy to the region where the tumor is located can be achieved, as a multi‐objective optimization problem to be solved via data driven surrogate model assisted optimization techniques. The performance results of K‐fold validation and hold‐out data sets for proposed data driven surrogate model are calculated using Mean Absolute Error metric which are obtained as 0.9 × 10−3 and 1.4 × 10−3 respectively. By observing the presented study case scenario, after 10 min of illumination with antenna array with optimally selected configurations, the targeted area (position of tumor) had reached to the critical temperature of 43 Celsius. Thus, it can be said that the proposed method is an efficient method, both in terms of (1) destroying tumor cells by heating without damaging the healthy cells, and (2) being a computationally efficient method.

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Dedicated 70 MHz RF systems for hyperthermia of challenging tumor locations

Cited by 5 publications

References 43 publications

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

Harnessing Immunotherapy to Enhance the Systemic Anti-Tumor Effects of Thermosensitive Liposomes

Harnessing immunotherapy to enhance the systemic anti-tumor effects of thermosensitive liposomes

A novel near field radiation shaping technique by using data driven surrogate based optimization for nondestructive hyperthermia

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