Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid

Pepe, Dominique; Phelps, Jessica; Lewis, Kevin; DuJack, Jared; Scarlett, Katrina; Jahan, Sumaya; Bonnier, Emilee; Milic-Pasetto, Tatjana; Hass, Martha A.; Lopes, Luciana B.

doi:10.1016/j.ijpharm.2012.06.016

Cited by 41 publications

(33 citation statements)

References 52 publications

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“…The interest in microemulsions as topical/transdermal delivery systems results from the multiple advantages that these systems present, as described below [8,9,26,27]. Some of the features described here are not exclusive of microemulsions and are displayed by other dermatological formulations and delivery systems.…”

Section: Why Use Microemulsions As Topical/transdermal Delivery Symentioning

confidence: 99%

“…This is most likely due to a stronger effect of the microemulsion containing mono- and diglycerides in increasing skin permeability, as measured by a reduction of skin electrical resistance. Decreasing the acyl chain length of unsaturated monoglycerides from 18 to eight carbons increased the penetration of lycopene, but not of ascorbic acid, in spite of the fact that the microemulsion containing the smaller monoglyceride decreased the skin electrical resistance (and thus, the barrier function) in a more pronounced manner [26]. This result suggests that the superiority of one oil phase mixture over the other also depends on the drug physicochemical properties.…”

Section: Microemulsion Composition Characteristics and Skin Penetmentioning

confidence: 99%

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Overcoming the Cutaneous Barrier with Microemulsions

Lopes

2014

Pharmaceutics

142

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Microemulsions are fluid and isotropic formulations that have been widely studied as delivery systems for a variety of routes, including the skin. In spite of what the name suggests, microemulsions are nanocarriers, and their use as topical delivery systems derives from their multiple advantages compared to other dermatological formulations, such as ease of preparation, thermodynamic stability and penetration-enhancing properties. Composition, charge and internal structure have been reported as determinant factors for the modulation of drug release and cutaneous and transdermal transport. This manuscript aims at reviewing how these and other characteristics affect delivery and make microemulsions appealing for topical and transdermal administration, as well as how they can be modulated during the formulation design to improve the potential and efficacy of the final system.

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Section: Why Use Microemulsions As Topical/transdermal Delivery Symentioning

confidence: 99%

Section: Microemulsion Composition Characteristics and Skin Penetmentioning

confidence: 99%

Overcoming the Cutaneous Barrier with Microemulsions

Lopes

2014

Pharmaceutics

142

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“…The reason for such behavior may be the fact that P2000, as a commercial product, contains around 47 % (m/m) of water and it might be possible that the bicontinuous structure was obtained directly by mixing S mix with the oil phase. These results indicate that APGs are not good surfactants for formula- a bicontinuous to inverted bicontinuous structure may be presumed (10). Hence, in this third region, the o/w structure was not completely developed.…”

Section: Characterization Of Colloidal Microstructurementioning

confidence: 85%

“…When Ф w exceeded 32 % (m/m), κ a rose rapidly until the system became turbid, because the number of water channels and clusters increased and the surfactant head groups became saturated with water. Because the second change in the slope at 32 % (m/m) of water is less visible, and due to high values of conductivity for the isotropic systems in the third region (with Ф w above 32 %, m/m), only the beginning of transition from a bicontinuous to inverted bicontinuous structure may be presumed (10). Hence, in this third region, the o/w structure was not completely developed.…”

Section: Characterization Of Colloidal Microstructurementioning

confidence: 97%

“…However, most APGs are commercially available as complex mixtures, making their phase behavior studies challenging, since the commercial blends may differ in the carbon chain length, glycosylation number and stereochemistry (4,5). In spite of a substantial amount of studies exploring APGs as surfactants for several types of applications, the literature describes few successful attempts dealing with the APG-based microemulsion systems as carriers for delivery of drugs or cosmeceuticals (2,(7)(8)(9)(10). Thus, in the present work, we employed the so-called biocompatible surfactants for microemulsion formation, two of them belonging to the group of rarely used APGs, decyl glucoside (Planatacare 2000 UP, P2000) and caprylyl/ capryl glucoside (Plantacare 810 UP, P810), intending to compare them with their ethoxylated counterparts.…”

mentioning

confidence: 99%

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Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

et al. 2017

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Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/ caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs. Keywords

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Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid

Cited by 41 publications

References 52 publications

Overcoming the Cutaneous Barrier with Microemulsions

Overcoming the Cutaneous Barrier with Microemulsions

Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

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