Decremental Conduction in Peripheral Nerve. Integration of Stimuli in the Neuron

Nó, R. Lorente de; Condouris, G. A.

doi:10.1073/pnas.45.4.592

Cited by 62 publications

(5 citation statements)

References 14 publications

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“…This then is consistent with the postulates of de No and Hebb that multineuronal sequences of activity are crucial to the functioning of the brain [1], [2].…”

Section: Discussionsupporting

confidence: 90%

“…In either case, the purpose of the mechanisms responsible for the cortical insensitivity that we observe could be to protect these stable circuit dynamical states, allowing them to function properly and rendering the UP state a special protected functional state. This then is consistent with the postulates of de No and Hebb that multineuronal sequences of activity are crucial to the functioning of the brain [1] , [2] .…”

Section: Discussionsupporting

confidence: 90%

“…Patterned neuronal activations have been postulated to be the potential neuronal scheme for informational representation [1] , [2] , but they have been relatively difficult to observe and study in the mammalian brain. Recently it has been discovered that such patterned activations arise during UP states, multineuronal depolarizations lasting between 500 milliseconds and 3 seconds in duration.…”

Section: Introductionmentioning

confidence: 99%

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UP States Protect Ongoing Cortical Activity from Thalamic Inputs

2008

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Cortical neurons in vitro and in vivo fluctuate spontaneously between two stable membrane potentials: a depolarized UP state and a hyperpolarized DOWN state. UP states temporally correspond with multineuronal firing sequences which may be important for information processing. To examine how thalamic inputs interact with ongoing cortical UP state activity, we used calcium imaging and targeted whole-cell recordings of activated neurons in thalamocortical slices of mouse somatosensory cortex. Whereas thalamic stimulation during DOWN states generated multineuronal, synchronized UP states, identical stimulation during UP states had no effect on the subthreshold membrane dynamics of the vast majority of cells or on ongoing multineuronal temporal patterns. Both thalamocortical and corticocortical PSPs were significantly reduced and neuronal input resistance was significantly decreased during cortical UP states – mechanistically consistent with UP state insensitivity. Our results demonstrate that cortical dynamics during UP states are insensitive to thalamic inputs.

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“…This then is consistent with the postulates of de No and Hebb that multineuronal sequences of activity are crucial to the functioning of the brain [1], [2].…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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UP States Protect Ongoing Cortical Activity from Thalamic Inputs

2008

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“…It can be seen in ( 2) that the initial spike has an amplitude of about 42.34 mV and the subsequent spikes have a slightly lesser amplitude which are 20.02 mv and 18.37 mv respectively. This is true as any neuronal signal undergoes decremental conduction as it travels down the fiber [22][23], [24] which is the phenomenon wherein an electrical signal weakens as it passes through a nerve fiber. Thus, the model validates the decremental conduction of neuronal signal appropriately.…”

Section: Figure 2 Normal Spike Trainmentioning

confidence: 99%

Insights into Nerve Signal Propagation: The Effect of Extracellular Space in Governing Neuronal Signal for healthy and injured Nerve Fiber using Modified Cable Model

Das,

Bujar Baruah,

Singh

et al. 2024

j.electron.electromedical.eng.med.inform

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Nerve injuries are complex medical conditions that may arise from a variety of traumatic events or diseases, altering the intricate structure of neural pathways. During neuronal injury, the potassium and sodium ion concentration that controls signaling endures significant changes such as the ion channels getting blocked or an increase in the intracellular ionic concentration. The Extracellular Space which surrounds a nerve fiber has a significant impact on the neuronal signal and variation in its size can alter neuronal signal transmission. Hence, to fully understand neuronal signal transmission, it is essential to explore the effect that the Extracellular Space exerts on the neuronal signal. The aim of this study is to develop a mathematical model which yields a simplistic yet robust mathematical expression of the nerve membrane potential, incorporating the Extracellular Space dependent parameters for having a holistic approach towards understanding neuronal signal transmission in healthy and injured nerve fiber. The conventional cable model focuses solely on the intrinsic properties of the nerve fiber, but the current work expands this model by incorporating the Extracellular Space dependent parameters into the final membrane potential expression. The results obtained from this study shows that certain combination of the Extracellular Space and fiber diameter could bring about hyperexcitation whereas in some cases it may lead to hypoexcitation to the neuronal signal as it propagates along the nerve fiber. Moreover, prolonged refractory period and delayed refractory period are also observed in certain combination of the Extracellular Space and fiber diameter. The proposed framework manages to show trends associated with certain medical conditions and may also be useful to further understand, and early diagnosis of various neurological conditions under the effect of an Extracellular Space of varied sizes.

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“…Rall vizsgálataiból az következik, hogy a disztálisabban elhelyezkedő szinapszisok hatása a sejtek kimenetét tekintve egyre kisebb (Rall, 1977;Spruston et al, 1994). Azonban már korán felmerült az a gondolat is, miszerint a dendriteknek szerepe lehet a szinaptikus bemenetek felerősítésében, és regeneratív feszültségek kialakításában (Chang, 1951a(Chang, , 1951bNo and Condouris, 1959), de technikailag csak sokkal később vált elérhetővé ezek detektálása (Llinas and Sugimori, 1980).…”

Section: Feszültségfüggő Ioncsatornák éS Szerepükunclassified

Két molekula sejtszintű kifejeződése patkány agyszövetben: a KCC2, mely közvetett módon, a posztszinaptikus GABA A receptor mediált sejtválaszban játszik szerepet, valamint a δ alegységgel rendelkező GABA A receptor, mely a tónusos áramok kialakításában vesz részt

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Decremental Conduction in Peripheral Nerve. Integration of Stimuli in the Neuron

Cited by 62 publications

References 14 publications

UP States Protect Ongoing Cortical Activity from Thalamic Inputs

UP States Protect Ongoing Cortical Activity from Thalamic Inputs

Insights into Nerve Signal Propagation: The Effect of Extracellular Space in Governing Neuronal Signal for healthy and injured Nerve Fiber using Modified Cable Model

Két molekula sejtszintű kifejeződése patkány agyszövetben: a KCC2, mely közvetett módon, a posztszinaptikus GABA A receptor mediált sejtválaszban játszik szerepet, valamint a δ alegységgel rendelkező GABA A receptor, mely a tónusos áramok kialakításában vesz részt

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