Abstract:Background:
Ethmoid or sphenoid intestinal-type adenocarcinomas (ITACs) form a distinct subtype of sinonasal adenocarcinomas that occur less than 1 case/100,000/yr. They have obvious exposure relationship to hardwood or leather dusts, infrequent metastasis, but a relatively high local-recurrence rate. They locate at sinuses close to vital structures listed as high-risk areas in surgeries. Even in expert hands, a craniofacial resection is associated with non-negligible mortality and morbidity. Mana… Show more
“…Data available to date show that there is a low incidence of EGFR , K‐RAS , and BRAF mutations and a high rate of increase in the number of EGFR copies. This genetic fingerprint seems to support the potential for anti‐ EGFR drugs 1145,1154 . Current evidence for use of anti‐ EGFR drugs is limited, but several clinical trials are ongoing for patients with metastatic disease 1157,1160 .…”
Section: Minor Salivary Gland Tumors Of the Sinonasal Tractmentioning
confidence: 83%
“…Systemic staging (e.g., total body CT, PET/CT) should be conducted once per year for the duration of the follow‐up as ITAC patients may develop distant metastatic disease 1146 . With such a surveillance protocol, earlier detection of recurrences increases the possibility to cure patients who experience relapses 1144,1154 . Globally, the recurrence rate after definitive treatment ranges from 17.6% to 49.6% 1155 .…”
Section: Minor Salivary Gland Tumors Of the Sinonasal Tractmentioning
BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved
“…Data available to date show that there is a low incidence of EGFR , K‐RAS , and BRAF mutations and a high rate of increase in the number of EGFR copies. This genetic fingerprint seems to support the potential for anti‐ EGFR drugs 1145,1154 . Current evidence for use of anti‐ EGFR drugs is limited, but several clinical trials are ongoing for patients with metastatic disease 1157,1160 .…”
Section: Minor Salivary Gland Tumors Of the Sinonasal Tractmentioning
confidence: 83%
“…Systemic staging (e.g., total body CT, PET/CT) should be conducted once per year for the duration of the follow‐up as ITAC patients may develop distant metastatic disease 1146 . With such a surveillance protocol, earlier detection of recurrences increases the possibility to cure patients who experience relapses 1144,1154 . Globally, the recurrence rate after definitive treatment ranges from 17.6% to 49.6% 1155 .…”
Section: Minor Salivary Gland Tumors Of the Sinonasal Tractmentioning
BackgroundSinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represents a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology‐based topics spanning the field.MethodsIn accordance with prior ICAR documents, ICSNT assigned each topic as an Evidence‐Based Review with Recommendations, Evidence‐Based Review, and Literature Review based on level of evidence. An international group of multidisciplinary author teams were assembled for the topic reviews using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses format, and completed sections underwent a thorough and iterative consensus‐building process. The final document underwent rigorous synthesis and review prior to publication.ResultsThe ICNST document consists of 4 major sections: general principles, benign neoplasms and lesions, malignant neoplasms, and quality of life and surveillance. It covers 48 conceptual and/or histopathology‐based topics relevant to sinonasal neoplasms and masses. Topics with a high level of evidence provided specific recommendations, while other areas summarized the current state of evidence. A final section highlights research opportunities and future directions, contributing to advancing knowledge and community intervention.ConclusionAs an embodiment of the multidisciplinary and collaborative model of care in sinonasal neoplasms and masses, ICSNT was designed as a comprehensive, international, and multidisciplinary collaborative endeavor. Its primary objective is to summarize the existing evidence in the field of sinonasal neoplasms and masses.This article is protected by copyright. All rights reserved
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