Decreasing rates of bone resorption in growing rats in vivo: Comparison of different types of bones

Li, X.Q.; Klein, L.

doi:10.1016/8756-3282(90)90056-5

Cited by 19 publications

(9 citation statements)

References 27 publications

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“…Although the female rat is generally well accepted as a model for human bone resorption [13], certain distinctions are important to note. The present study supports previous work [7,9,10] showing elevated rates of bone resorption during periods of growth and reduced rates during adulthood. Because this study examined animals with intact ovaries, however, our aged rat model more closely represents an estrogen-replete adult condition rather than an estrogen-deficient postmenopausal condition.…”

Section: Discussionsupporting

confidence: 95%

“…Previous investigators have suggested that urinary markers of bone resorption may respond differently to treatment in acute and chronic conditions [5] and may demonstrate alterations in sensitivity with age [9,10]. Chronic tetracycline labeling has been developed and validated as a sensitive technique to monitor bone resorption in young rats, but is not commonly used in older animals because of logistical (cost and nature of radioactive waste disposal) and biological factors (lower rate of bone turnover associated with adulthood).…”

Section: Discussionmentioning

confidence: 99%

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Urinary 3 H-Tetracycline and Pyridinium Crosslinks Differ in Their Response to Calcium Restriction in Mature and Aged Rats

Talbott

Chowdhury

Shapses

1999

Calcified Tissue International

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The aim of this study was to evaluate bone resorption (BR) in rats by two methods: chronic 3H-tetracycline labeling (3HTC) and pyridinium crosslink excretion (PYDX), and compare the sensitivity of these markers in two age groups. Female Sprague-Dawley rats at 12-29 weeks of age ("mature", n = 12) and at 40-57 weeks of age ("aged", n = 22) were examined. Skeletal incorporation of 3HTC in aged rats was 43 +/- 8% of that in mature animals (P < 0.01), indicating an age-related decrease in bone turnover. BR was modulated over 9 weeks by calcium restriction (CR), measured by urinary excretion of both 3HTC and PYDX, and compared with age-matched, calcium-adequate controls. At baseline, urinary excretion of 3HTC was not significantly different between age groups, whereas urinary PYDX was 14-20% higher in mature compared with aged rats (P < 0.01). CR produced a 32-39% peak increase in BR (P < 0.01) compared with controls that did not differ significantly between marker or age group. Urinary 3HTC was elevated at weeks 1-3 (P < 0. 01) and reached maximal values at week 2 (32 +/- 17%). Urinary PYDX, however, was not elevated until week 2, reached maximal levels at week 3 (39 +/- 15%), and remained elevated until week 6 (P < 0.01). These data indicate that although both markers are elevated by CR, marker response differs with age, and variability exists for acute and chronic responses.

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Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Urinary 3 H-Tetracycline and Pyridinium Crosslinks Differ in Their Response to Calcium Restriction in Mature and Aged Rats

Talbott

Chowdhury

Shapses

1999

Calcified Tissue International

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“…Times for peak growth and mineralization differ between trabecular and cortical bone (9). Thus, in addition to differences in the proportions of cortical and trabecular bone (10) and rates of resorption (11), vertebrae have a longer potential growth period than long bones in rats and humans because closure of the growth plate occurs later in the axial skeleton than in the appendicular skeleton (12,13). Therefore, bones in the axial and appendicular skeletal areas may respond differently to the same nutritional factors.…”

Section: Hm25072@uafsysbuarkedumentioning

confidence: 99%

Relation of boron to the composition and mechanical properties of bone.

McCoy

Kenney

Montgomery

et al. 1994

Environ Health Perspect

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A review of the experimental studies relating boron to biological effects on appendicular and axial bones in animal models suggests that numerous influences, known and unknown, affect the responsiveness of bone to dietary boron. Degrees of skeletal response to boron are modified by other nutritional variables that include calcium, magnesium, vitamin D, and fluoride. Evidence suggests that appendicular and axial bones may differ in their responses. Tests of the mechanical properties of bones may provide useful criteria for assessing the impacts of boron status on bone. These tests might resolve questions about optimal intakes of boron because mechanical properties sometimes respond to boron when composition of bones does not. Difficulty in interpreting some of the existing research arises because of the incipient state of knowledge regarding boron nutriture, to analytical problems associated with determining accurately the small quantities of boron in feed and tissues, and to technological difficulties in controlling extraneous exposure of experimental animals to boron. Yet there is considerable evidence that both compositional and functional properties of bone are affected by boron status. -Environ Health Perspect 102(Suppl 7): 49-53 (1994)

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“…Previous studies have shown that different types of bones have differences in bone formation and bone resorption (Culliton, 1987;Li and Klein, 1990). The preferential loss of cancellous bone is Fig.…”

Section: Discussionmentioning

confidence: 99%

A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice

Weerachayaphorn

Chuncharunee

Mahagita

et al. 2011

Journal of Ethnopharmacology

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Decreasing rates of bone resorption in growing rats in vivo: Comparison of different types of bones

Cited by 19 publications

References 27 publications

Urinary 3 H-Tetracycline and Pyridinium Crosslinks Differ in Their Response to Calcium Restriction in Mature and Aged Rats

Urinary 3 H-Tetracycline and Pyridinium Crosslinks Differ in Their Response to Calcium Restriction in Mature and Aged Rats

Relation of boron to the composition and mechanical properties of bone.

A protective effect of Curcuma comosa Roxb. on bone loss in estrogen deficient mice

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