Decreasing Medication of Intraocular Pressure in Open Angle Glaucoma

Abstract

The primary open-angle glaucomas (POAG) are multi-factorial, chronic, progressive and bilateral optic neuropathies characterized by morphological changes at the optic nerve head and retinal nerve fiber layer in the absence of other ocular disease or congenital anomalies. These changes are associated with progressive retinal ganglion cells death and visual field loss. Simultaneously with the nerve fiber layer loss occurs an activation of glial cells and tissue reshaping which lead to the characteristic excavation of the optic nerve (ON) and a reduction of the blood flow.Among the risk factors involved in glaucoma, the intraocular pressure (IOP) is the principal and most known. In the present, the goal of the "classical" treatment in glaucoma (drugs, laser, surgery) is to decreased IOP until values to not endanger ON. There are cases in which (IOP) is reduced until minimum acceptable values, but, glaucomatous optic neuropathy (GON) continues to evolve.