Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women

Lai, Guan Lin; Yeh, Chih Ching; Yeh, Ching Ying; Chen, Ruey Yu; Fu, Chiung Lin; Chen, Chi Huang; Tzeng, Chii Ruey

doi:10.1016/j.reprotox.2017.09.001

Cited by 28 publications

(46 citation statements)

References 51 publications

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“…A positive relationship between lead and endometriosis (adjusted OR = 2.59, 95% CI = 1.11-6.06) was found in Asian women whereas zinc levels were inversely associated with the disease (adjusted OR = 0.39, 95% CI = 0.18-0.88) [77]. While cadmium (Cd) levels were greater in women with endometriosis, the adjusted odds ratio was not significant [77].…”

Section: Metalsmentioning

confidence: 99%

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

Freger¹,

Foster²

2021

Endometriosis

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Endometriosis is widely acknowledged to be an estrogen dependent disease or unknown etiology. Recognition that environmental toxicants can bind with and activate the estrogen receptor, dysregulate steroid metabolism and, in some cases, act as anti-androgenic substances (phthalate esters) has led to proposal that exposure to environmental toxicants are associated with increased risk of endometriosis. Since our last review of the subject in 2008, the literature has expanded with several epidemiological and biomonitoring studies suggesting a potential association, whereas others have been unable to demonstrate a link between exposure and enhanced risk. Therefore, we carried out a systematic review and critical appraisal of the literature published over the past decade (2009-2019). The majority of studies found dealt with exposure to polychlorinated biphenyls (PCBs), dioxins, dioxin-like and non-dioxin-like compounds, bisphenol A and phthalate esters. Several studies suggest a potential association between exposure to environmental toxicants; however, important weaknesses in study design, methodology, and analysis together with many contradictory studies weaken confidence in these associations. Consequently, we conclude that despite a growing literature, evidence for an association between exposure to environmental toxicants and risk of endometriosis remains weak.

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Section: Metalsmentioning

confidence: 99%

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

Freger¹,

Foster²

2021

Endometriosis

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“…The descriptive investigations of exposure to metals appear to be more homogeneous in the outcomes. Cross-sectional studies hypothesized an involvement of cadmium [37] and lead [42] in the onset of the disease. However, data were collected using self-reported questionnaires; hence, possible biases cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

Caporossi

Capanna

Viganò

et al. 2021

IJERPH

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Endometriosis is a gynecological disorder characterized by the presence of endometrial stroma and glands outside the uterine cavity. A systematic review of the literature was conducted to clarify, starting from environmental exposure data, whether possible occupational risk factors may correlate with the onset of the disease. The guidelines for reporting systematic reviews of the “PRISMA” statement were followed and two databases, Scopus and PubMed, were used. Of the 422 studies selected with specific keywords, 32 publications were eligible, 28 of which referred to chemical agents and 4 related to night work. Conflicting data emerged among these studies. Although some compounds seemed to be more involved than others in the onset of endometriosis. Association with exposure to organochlorine compounds is the most supported by the epidemiological data, while other pesticide exposure did not show any clear correlation. Likewise, the hypothesis of a correlation with perfluoroalkyls exposure is not currently supported by data. The involvement of metals as risk factors has not been confirmed, while the role of night work, in the case of long service, seems to play an etiological role. In order to clarify the potential occupational risk of endometriosis development, well-designed studies are needed to evaluate the potential association between chemical compounds and disease etiology.

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“…Thus, it is suggested that antioxidants, including zinc, may play a role in endometriosis due to its function as an antioxidant, anti-inflammatory and immune regulation factor. Some clinical studies report lowered serum zinc concentrations in women with endometriosis, suggesting that zinc maybe involved in the multifactorial pathogenesis of this disease [98][99][100][101]. Furthermore, it has been noted that women with endometriosis might experience increased oxidative stress parameters [102].…”

Section: Zinc and Endometriosismentioning

confidence: 99%

The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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Decreased zinc and increased lead blood levels are associated with endometriosis in Asian Women

Cited by 28 publications

References 51 publications

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

The Link between Environmental Toxicant Exposure and Endometriosis Re-Examined

From Environmental to Possible Occupational Exposure to Risk Factors: What Role Do They Play in the Etiology of Endometriosis?

The Role of Zinc in Selected Female Reproductive System Disorders

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