Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia

Zhou, Shiyu; Suzuki, Michio; Hagino, Hirofumi; Takahashi, Tsutomu; Kawasaki, Yasuhiro; Nohara, Shigeru; Yamashita, Iwao; Seto, Hikaru; Kurachi, Masayoshi

doi:10.1016/s0006-3223(03)00007-6

Cited by 122 publications

(76 citation statements)

References 56 publications

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“…Absence of anisotropic asymmetry in schizophrenia might be related to functional disconnection as well as a disturbance in thalamic filtering in this group. Zhou et al (2003) reported right-greater-than-left asymmetry in the volumes of anterior limb in both controls and patients with schizophrenia, although the schizophrenia group showed significantly increased asymmetry compared with controls. However, our voxel-based approach showed reduced, right-greater-than-left asymmetry of fractional anisotropy in schizophrenia.…”

Section: Asymmetry Of Fractional Anisotropy In White Matter Of Normalmentioning

confidence: 88%

“…Alterations in white matter asymmetry in schizophrenia have also been exploited using DT-MRI, in studies looking at the cingulum bundle and uncinate fasciculus (Kubicki et al, 2002Zhou et al, 2003). These latter studies follow closely in time the first DT-MRI studies of schizophrenia (Buchsbaum et al, 1998;Lim et al, 1999).…”

Section: Introductionmentioning

confidence: 92%

“…White matter asymmetry has been explored primarily in studies of white matter volume of structures or in voxel-based concentration of white matter among subjects using structural MRI (Good et al, 2001;Pujol et al, 2002;Zhou et al, 2003). The recent advent of diffusion tensor magnetic imaging (DT-MRI) techniques (Basser et al, 1994), however, makes it possible to measure the quality of the neuronal fiber bundles within white matter regions of interest (ROI).…”

Section: Introductionmentioning

confidence: 99%

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White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

et al. 2004

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Hemisphere asymmetry was explored in normal healthy subjects and in patients with schizophrenia using a novel voxel-based tensor analysis applied to fractional anisotropy (FA) of the diffusion tensor. Our voxel-based approach, which requires precise spatial normalization to remove the misalignment of fiber tracts, includes generating a symmetrical group average template of the diffusion tensor by applying nonlinear elastic warping of the demons algorithm. We then normalized all 32 diffusion tensor MRIs from healthy subjects and 23 from schizophrenic subjects to the symmetrical average template. For each brain, six channels of tensor component images and one T2-weighted image were used for registration to match tensor orientation and shape between images. A statistical evaluation of white matter asymmetry was then conducted on the normalized FA images and their flipped images. In controls, we found left-higher-than-right anisotropic asymmetry in the anterior part of the corpus callosum, cingulum bundle, the optic radiation, and the superior cerebellar peduncle, and right-higher-than-left anisotropic asymmetry in the anterior limb of the internal capsule and the anterior limb's prefrontal regions, in the uncinate fasciculus, and in the superior longitudinal fasciculus. In patients, the asymmetry was lower, although still present, in the cingulum bundle and the anterior corpus callosum, and not found in the anterior limb of the internal capsule, the uncinate fasciculus, and the superior cerebellar peduncle compared to healthy subjects. These findings of anisotropic asymmetry pattern differences between healthy controls and patients with schizophrenia are likely related to neuro-developmental abnormalities in schizophrenia.

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Section: Asymmetry Of Fractional Anisotropy In White Matter Of Normalmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

et al. 2004

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“…Patients with both conditions show white matter density reductions in the anterior limb of the internal capsule (ALIC) and in prefrontal subgyral white matter using T 1 -weighted magnetic resonance imaging (MRI). 2,3 These abnormalities are shared by unaffected relatives in proportion to their proximity to an affected subject. 4 These findings suggest that white matter density reductions are likely to be associated with shared genetic factors, although no specific genetic variants have yet been found which account for these findings.…”

Section: Introductionmentioning

confidence: 99%

The effects of a neuregulin 1 variant on white matter density and integrity

et al. 2007

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Theories of abnormal anatomical and functional connectivity in schizophrenia and bipolar disorder are supported by evidence from functional magnetic resonance imaging (MRI), structural MRI and diffusion tensor imaging (DTI). The presence of similar abnormalities in unaffected relatives suggests such disconnectivity is genetically mediated, albeit through unspecified loci. Neuregulin 1 (NRG1) is a psychosis susceptibility gene with effects on neuronal migration, axon guidance and myelination that could potentially explain these findings. In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 (SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density (T 1 -weighted MRI) and integrity (DTI) was ascertained. Subjects with the riskassociated TT genotype had reduced white matter density in the anterior limb of the internal capsule and evidence of reduced structural connectivity in the same region using DTI. We therefore provide the first imaging evidence that genetic variation in NRG1 is associated with reduced white matter density and integrity in human subjects. This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination.

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“…On the other hand, superior longitudinal fasciculus is the main white matter tract that connects frontal-parietal regions. Recently, reduced integrity in anterior thalamic radiation and superior longitudinal fasciculus has been reported (41)(42)(43)(44)(45). Besides, a correlation has been found between negative symptoms, cognitive impairment, and white matter disintegrity within these white matter tracts (46,47).…”

Section: Discussionmentioning

confidence: 95%

A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology

Onay¹,

Eser²,

Ulasoglu-Yildiz³

et al. 2017

Diagn Interv Radiol

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Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia

Cited by 122 publications

References 56 publications

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

White matter hemisphere asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study

The effects of a neuregulin 1 variant on white matter density and integrity

A combined VBM and DTI study of schizophrenia: bilateral decreased insula volume and cerebral white matter disintegrity corresponding to subinsular white matter projections unlinked to clinical symptomatology

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