2019
DOI: 10.1101/616144
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Decreased viability and neurite length in neural cells treated with chitosan-dextran sulfate nanocomplexes

Abstract: CXCL12 is a chemokine known to regulate migration, proliferation, and differentiation of neural stem cells (NSCs) and to play a neuroprotective role in ischemic stroke. Chitosan-dextran sulfate nanocomplexes (Ch/DS NC) are known nanoparticulated systems used to efficiently deliver heparin-binding factors. Here we evaluate Ch/DS NC as carriers for CXCL12 in a model of stroke, and, surprisingly, found evidence of Ch/DS NC-induced brain lesion.Neurotoxic screening revealed that Ch/DS NC reduced neuronal viability… Show more

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