Decreased Urinary Sodium-to-urinary Creatinine Ratio Identifies Sodium Depletion in Pediatric Acute Gastroenteritis

Abstract

The majority of AG patients was found to have NNaD as determined by uNa/uCr and FENa. Calculation of uNa/uCr may be useful for diagnosing NNaD in AG.

Low sodium status in cystic fibrosis—as assessed by calculating fractional Na + excretion—is associated with decreased growth parameters

“…Our study supports the hypothesis that many CF patients may suffer from sodium deprivation even if their plasma sodium concentrations are normal [15]. We found that a majority of normonatremic CF patients (71.4%) had calculated FE Na values of less than 0.5%, which is the previously reported lower limit of normal sodium status [15,16,19]. Accordingly, the mean FE Na value of CF group I was significantly lower than that of group II with patients having normal FE Na values above 0.5%, and that of normal controls (Table 3).…”

“…This may be particularly true for subjects with a known risk for enhanced sodium loss such as patients with renal salt-losing disorders, chronic diarrhea, ileostomy and CF. In this situation, and in the light of the limited ability of plasma or urine sodium concentration measurements to accurately assess body sodium balance, calculation of the fractional excretion of sodium which indicates the percentage of filtered sodium excreted in urine may be a useful tool [15,16]. FENa values below 0.5% have been reported to be associated with low sodium status and have been shown to accurately identify states of low sodium balance [15,16].…”

“…In this situation, and in the light of the limited ability of plasma or urine sodium concentration measurements to accurately assess body sodium balance, calculation of the fractional excretion of sodium which indicates the percentage of filtered sodium excreted in urine may be a useful tool [15,16]. FENa values below 0.5% have been reported to be associated with low sodium status and have been shown to accurately identify states of low sodium balance [15,16]. Moreover, calculation of the FE Na compensates for urine flow rate and thus may reflect sodium status more appropriately than measurement of urine sodium concentrations alone.…”

Congenital Sodium Diarrhea

“…Urinary Na þ concentration, as a marker of body Na þ depletion, is sometimes found to be low before and during inadequate fluid and sodium supplementation. Fractional sodium excretion may be a better marker of sodium status in these patients because it is independent of urine flow (12,13). Other laboratory findings include metabolic acidosis and alkaline fecal pH.…”

Congenital sodium diarrhea

“…Концентрация Na + в моче, как маркер истощения Na + в организме, иногда оказывается низкой до и во время неадекватного приема жидкости и натрия. Фракционная экскреция натрия может быть лучшим маркером статуса натрия у этих пациентов, поскольку он не зависит от потока мочи [22,30]. Другие характерные лабораторные данные включают метаболический ацидоз и щелочной рН фекалий (рН кала >7,5).…”