Decreased uptake in bone scans ('cold lesions') in metastatic carcinoma. Two case reports.

Kim, E E; DeLand, Frank H.; Maruyama, Y

doi:10.2106/00004623-197860060-00025

Cited by 4 publications

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“…radiographic survey or serum alkaline phosphatase [4,5]. Also confirmed are more common métastasés of renal cell carcinoma to the axial skeleton with predo minantly increased uptake of the radioactivity [7], 'Cold' lesions (decreased activities) in bone scans have been reported in mostly osteolytic métastasés from lung or breast carcinomas to vertebrae, bone struc tures that have an extensive blood supply [8], Our study demonstrates 7 'cold' lesions by renal cell car cinoma; one example is presented in figures 1 and 2. These are probably related to aggressive destructive process not accompanied by significant osteoblastic activity or hyperemia.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Radionuclide Images and Radiographs for Skeletal Metastases from Renal Cell Carcinoma

et al. 1983

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68 metastatic bone lesions proven by biopsy, follow-up radionuclide bone imaging, or radiographs in 18 patients with surgically confirmed renal cell carcinoma were retrospectively analyzed. Bone imaging demonstrated 62 lesions (91%): 48 definite, 7 questionable ‘hot’ lesions, and, 2 definite, 5 questionable ‘cold’ lesions. The spine was the most common site. 15 patients had more than one metastasis. 27 lesions were undiscovered by radiographs. Serum alkaline phosphatase was elevated in 12 of 18 patients. It is concluded that radionuclide bone imaging is more sensitive than radiographic examination for bony metastasis from renal cell carcinoma, and that it is important to recognize ‘cold’ metastatic lesions on the bone imaging in patients with renal cell carcinoma.

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Section: Discussionmentioning

confidence: 99%