Decreased thalamic glutamate level in unmedicated adult obsessive–compulsive disorder patients detected by proton magnetic resonance spectroscopy

Zhu, Yajing; Fan, Qing; Han, Xu; Zhang, Haiyin; Chen, Jue; Wang, Zhen; Zhang, Zongfeng; Tan, Lian; Xiao, Zeping; Tong, Shanbao; Maletić-Savatić, Mirjana; Li, Yao

doi:10.1016/j.jad.2015.03.008

Cited by 40 publications

(32 citation statements)

References 77 publications

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“…In the present study, although the positive correlation between decreased VMHC in the thalamus and compulsion disappeared after Bonferroni correction, we speculate that the impaired intrinsic interhemispheric functional homotopy in the thalamus might be associated with the regulation of compulsive behavior. Previous studies have also demonstrated increased gray matter volume, decreased regional spontaneous neuronal activity and homogeneity, and reduced glutamate level in the thalamus, which were also related to the clinical symptoms of OCD [3,6,7,12,42]. Taking these findings together, we have reason to speculate that the anatomical and functional abnormalities in the thalamus are widely implicated in OCD, and our findings provide new evidence that abnormalities in the CSTC circuitry underlie the pathophysiological mechanisms of OCD.…”

Section: Research Ping LIsupporting

confidence: 77%

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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Neuroimaging studies have shown structural and functional abnormalities in parts of the cortico-striato-thalamo-cortical (CSTC) brain circuitry in patients with obsessive-compulsive disorder (OCD). However, little is known about changes in the interhemispheric functional homotopy in the resting-state in OCD. This study used a voxel-mirrored homotopic connectivity (VMHC) approach combined with resting-state functional magnetic resonance imaging to investigate changes in interhemispheric functional homotopy in 60 OCD patients and 60 healthy controls. Compared with the healthy controls, the OCD patients showed decreased VMHC values in the thalamus. The results suggest that changes in functional homotopy in the CSTC circuitry may be involved in the pathophysiologic mechanism of OCD. Our findings provide new evidence of abnormalities in the CSTC circuitry in OCD.

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Section: Research Ping LIsupporting

confidence: 77%

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Wang¹,

Chen²,

Li³

et al. 2018

Neuropsychiatry

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“…Also, an estimated 30% of patients do not adequately respond to first‐line treatments and complete functional recovery is rare. Varied individual response rates to SSRIs as well as the possible benefit of augmentation therapy with other agents such as antipsychotics further implicate role of other neurobiologic factors in pathophysiology of OCD …”

Section: What Is Known and Objectivementioning

confidence: 99%

“…Recent evidence suggests that abnormalities of the glutamatergic system may play role in the pathophysiology of OCD . In this regard, dysregulation of the cortico‐striatale‐thalamocortical (CSTC)may be a key component, as disruption of glutamatergic transmission – the main excitatory transmitter of this circuitry – has been reported in several studies of patients with OCD.…”

Section: What Is Known and Objectivementioning

confidence: 99%

N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial

et al. 2016

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“…According to five independent family based‐association studies, as well as a case‐control study, the SLC1A1 gene is most consistently associated with OCD . Disruption of glutamatergic transmission in the cortico‐striatal‐thalamo‐cortical (CSTC) circuitry plays a role in OCD pathogenesis . Higher glutamate concentrations in cerebrospinal fluid of patients with OCD compared to control groups have been reported .…”

Section: What Is Known and Objectivementioning

confidence: 99%

“…[6][7][8][9][10][11] Disruption of glutamatergic transmission in the cortico-striatal-thalamo-cortical (CSTC) circuitry plays a role in OCD pathogenesis. 12,13 Higher glutamate concentrations in cerebrospinal fluid of patients with OCD compared to control groups have been reported. 14 Moreover, a decreased amount of glutamate in the anterior cingulate cortex of children with OCD has been observed.…”

Section: What Is K Nown and Objec Tivementioning

confidence: 99%

Genetic and pharmacogenetic study of glutamate transporter (SLC1A1) in Iranian patients with obsessive-compulsive disorder

et al. 2018

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Summary What is known and objective Obsessive‐compulsive disorder (OCD) is a chronic neuropsychiatric disorder. Selective serotonin reuptake inhibitors (SSRIs) are the first line of medication for OCD treatment; however, 40%‐60% of patients with OCD do not respond to SSRIs adequately. There are growing pieces of evidence which suggest a significant role for the glutamatergic system in the genesis of OCD and its consequent treatment. In the present study, we aimed to assess the association of SLC1A1 polymorphisms (rs301430, rs2228622 and rs3780413) with OCD and its clinical characteristics, as well as the importance of these SNPs in the response of OCD patients to SSRI pharmacotherapy. Methods Sample study consisted of 243 OCD cases and 221 control subjects. Patients were treated 12 weeks with fluvoxamine (daily dose: 150‐300 mg). Based on the reduction in obsessive and compulsive severity scores using Y‐BOCS severity scale, patients were classified as responders, non‐responders and refractory. A total of 239, 228 and 215 patients were genotyped for rs301430, rs2228622 and rs3780413, respectively, by the means of PCR‐RFLP. Results and discussion No association was detected between SLC1A1 SNPs and OCD, except an association between the familial form of the disease in males with rs2228622 (P = 0.033). The results of pharmacogenetic studies revealed the associations of two SLC1A1 SNPs, rs2228622 (P = 0.031) and rs3780413 (P = 0.008), with treatment response. What is new and conclusion Results of the current study suggest a role for the glutamate transporter in OCD treatment response with SSRIs which should encourage researchers to further investigate the importance of glutamate transporter in OCD pharmacogenetics.

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Decreased thalamic glutamate level in unmedicated adult obsessive–compulsive disorder patients detected by proton magnetic resonance spectroscopy

Cited by 40 publications

References 77 publications

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

Reduced Interhemispheric Resting-State Functional Homotopy in Obsessive-Compulsive Disorder

N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial

Genetic and pharmacogenetic study of glutamate transporter (SLC1A1) in Iranian patients with obsessive-compulsive disorder

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