Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy

Xu, Su; Zhu, Wenjun; Wan, Yamin; Wang, Jiabei; Chen, Xi; Pi, Liya; Lobo, Mary Kay; Ren, Bin; Zhao, Ying; Morris, Michael; Cao, Qi

doi:10.1177/1536012117749051

Cited by 10 publications

(9 citation statements)

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“…In vivo magnetic resonance spectroscopy measurement of ethanol metabolites. In vivo MRS experiments were performed on a Bruker BioSpec 70/30USR Advance III 7T horizontal bore MR scanner (Bruker Biospin MRI) as described previously 65,66 . All mice were weighed, anaesthetized and placed in a prone position on a specially designed cradle and inserted into the MR scanner for a baseline measurement.…”

Section: Single-cell Mass Spectrometry (Gc-ms/ms)mentioning

confidence: 99%

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

et al. 2021

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to ethanol-induced acute intoxication and alcohol preference in mice 13-15. Several neuroimaging studies have demonstrated that the uptake of acetate is significantly increased in the cerebellum and other brain areas after ethanol consumption in people with alcohol use disorder 14,16. The cerebellum is a primary brain region involved in alcohol metabolism and alcohol motor impairment. However, recent studies provide strong evidence for cerebellar contributions to non-motor functions such as cognition, language, emotions and social behaviours 17-19. The cerebellum also plays a role in many clinical neurological conditions, including attention deficit hyperactivity disorder, schizophrenia, bipolar disorder, major depressive disorder and anxiety disorders 20-22. Relative to the most frequently investigated brain regions, for example, the amygdala and basal ganglia, the cerebellum has been largely overlooked regarding its impact on neurological mechanisms underlying alcohol use disorder. Nevertheless, it remains unclear whether there is a central target that mediates ethanol-derived acetate production and acetate-induced behaviours. Specifically, we have only limited knowledge about the possible role of brain ALDH2 in alcohol metabolism and alcohol intoxication. One major barrier to our understanding of brain ALDH2 is a lack of specific approaches to distinguish between central and peripheral ALDH2-mediated

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Section: Single-cell Mass Spectrometry (Gc-ms/ms)mentioning

confidence: 99%

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

et al. 2021

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“…One of the criteria for a successful animal model of alcoholism is the demonstration of physical dependence per se must be unequivocally attributed to the chronic administration and subsequent removal of ethanol. Common models to induce physical dependence to alcohol (cf., Mello, 1973) include exposure to ethanol via drinking (e.g., Xu et al, 2018), intraperitoneal (i.p.) (e.g., Liew et al, 2016) or intragastric (i.g.)…”

Section: From Mice To Men—translational Imaging Findingsmentioning

confidence: 99%

Neuroimaging in alcohol use disorder: From mouse to man

Fritz

Klawonn

Zahr

2019

J of Neuroscience Research

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This article provides an overview of recent advances in understanding the effects of alcohol use disorders (AUD) on the brain from the perspective of magnetic resonance imaging (MRI) research in preclinical models and clinical studies. As a noninvasive investigational tool permitting assessment of morphological, metabolic, and hemodynamic changes over time, MRI offers insight into the dynamic course of alcoholism beginning with initial exposure through periods of binge drinking and escalation, sobriety, and relapse and has been useful in differential diagnosis of neurological diseases associated with AUD. Structural MRI has revealed acute and chronic effects of alcohol on both white and gray matter volumes. MR Spectroscopy, able to quantify brain metabolites in vivo, has shed light on biochemical alterations associated with alcoholism. Diffusion tensor imaging permits microstructural characterization of white matter fiber tracts. Functional MRI has allowed for elucidation of hemodynamic responses at rest and during task engagement. Positron emission tomography, a non‐MRI imaging tool, has led to a deeper understanding of alcohol‐induced receptor and neurotransmitter changes during various stages of drinking and abstinence. Together, such in vivo imaging tools have expanded our understanding of the dynamic course of alcoholism including evidence for regional specificity of the effects of AUD, hints at mechanisms underlying the shift from casual to compulsive use of alcohol, and profound recovery with sustained abstinence.

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“…Accepted for publication Apr 23, 2021. doi: 10.21037/qims- View this article at: http://dx.doi.org/10.21037/qims- to neuronal degeneration, while decreased NAA/mI could be more suitable for monitoring AD progression (21,22). They use metabolite ratios rather than absolute concentrations, which has been challenged since tCr could have abnormal levels (23,24) and thus, it is hard to draw definite conclusions on which of the two metabolites in the ratio was responsible for the distinction. There are some reports of tCr values changing across the MCI-AD spectrum (25,26).…”

Section: Introductionmentioning

confidence: 99%

Brain neurometabolites differences in individuals with subjective cognitive decline plus: a quantitative single- and multi-voxel proton magnetic resonance spectroscopy study

Yang¹,

Xing²,

Zhao³

et al. 2021

Quant Imaging Med Surg

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Background: Subjective cognitive decline plus could be an extremely early phase of Alzheimer's disease; however, changes of N-acetylaspartate, myoinositol, and N-acetylaspartate/myoinositol is still unknown at this stage. This study aimed to explore brain neurometabolic alterations in patients with subjective cognitive decline plus using quantitative single-voxel and multi-voxel 1H-magnetic resonance spectroscopy.Methods: A total of 91 participants were enrolled and underwent a GE 3.0-T magnetic resonance imaging, including 33 elderly controls, 27 patients with subjective cognitive decline plus, and 31 patients with amnestic mild cognitive impairment (MCI). Single-voxel and multi-voxel 1H-magnetic resonance spectroscopy were used to investigate the differences in neurometabolite levels among the three groups.Results: Compared with elderly controls, patients with subjective cognitive decline plus showed significant decline in N-acetylaspartate and N-acetylaspartate/ myoinositol values in multiple regions, and amnestic MCI participants demonstrated more significant decreased N-acetylaspartate and N-acetylaspartate/ myoinositol levels in multiple regions. The combined concentrations of N-acetylaspartate with myoinositol showed an excellent discrimination between those with subjective cognitive decline plus and elderly controls as compared to that obtained using N-acetylaspartate/myoinositol ratios with the area under the receiver operating characteristic curve of 0.895 and 0.860, respectively. Likewise, the combined area under the curve for differentiating patients with subjective cognitive decline plus from amnestic MCI was obtained using the combined levels of N-acetylaspartate with myoinositol was 0.892. This was also higher than the combined area under the curve of 0.836 obtained using N-acetylaspartate/myoinositol ratios. Moreover, N-acetylaspartate levels in the left hippocampus and left posterior cingulate cortex (PCC) was positively related to the Auditory Verbal Learning Test delayed recall scores in patients with subjective cognitive decline plus, whereas only the N-acetylaspartate/myoinositol ratio was positively related to this scale scores in the left hippocampus.Conclusions: Quantitative single-voxel and multi-voxel 1H-magnetic resonance spectroscopy can provide valuable information to detect alterative brain neurometabolites characteristics in patients with subjective

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Decreased Taurine and Creatine in the Thalamus May Relate to Behavioral Impairments in Ethanol-Fed Mice: A Pilot Study of Proton Magnetic Resonance Spectroscopy

Cited by 10 publications

References 71 publications

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication

Neuroimaging in alcohol use disorder: From mouse to man

Brain neurometabolites differences in individuals with subjective cognitive decline plus: a quantitative single- and multi-voxel proton magnetic resonance spectroscopy study

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